Synthesis And Antimicrobial Activities Of Novel 2- Methoxy-6- 3-Alkyl-4 5-Dihydro-1H-1 2 4-Triazol-5-One-4-Yl -Azomethin -Phenyl Benzoates With Their Nonaqueous Medium Titrations
Yazarlar (5)
Abdurrahman Gürbüz
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Prof. Dr. Muzaffer ALKAN Kafkas Üniversitesi, Türkiye
Doç. Dr. Sevda MANAP Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Gül ÖZDEMİR TORAMAN Kafkas Üniversitesi, Türkiye
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (Diğer hakemli uluslarası dergilerde yayınlanan tam makale) | ||
| Dergi Adı | World Journal of Pharmacy and Pharmaceutical Sciences | ||
| Dergi ISSN | 2278-4357 | ||
| Dergi Tarandığı Indeksler | CAS | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2021 |
| Cilt / Sayı / Sayfa | 10 / 9 / 65–80 | DOI | 10.20959/wjpps20219-19820 |
| Makale Linki | https://www.wjpps.com/Wjpps_controller/abstract_id/14963 | ||
| UAK Araştırma Alanları |
Organik Kimya
Biyokimya
Spektroskopi
|
||
| Özet |
| A series of novel 2-methoxy-6-[(3-alkyl-4, 5-dihydro-1H-1, 2, 4-triazol-5-one-4-yl)-azomethin]-phenyl benzoates (4) were synthesized from the reactions of 3-alkyl-4-amino-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (2) with 2-benzoxy-3-methoxybenzaldehyde (3). The acetylation reactions of compounds 4 were investigated and compounds 5 were thus obtained. The structures of fourteen new compounds were characterized from IR, 1 H NMR, 13 C NMR and UV spectral data. In addition, 4 and 5 type compounds were examined for their in vitro potential antibacterial activities. Antimicrobial activity was determined on five bacteria using the agar well diffusion method. Furthermore, the newly synthesized 4 type compounds were titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in four non-aqueous solvents, including isopropyl alcohol, tert-butyl alcohol, N, N-dimethylformamide (DMF) and acetone. The half-neutralization potential (HNP) values and the corresponding pKa values were determined for all cases. Thus, the effects of solvents and molecular structure upon acidity were investigated. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 7 |