Synthesis, In Vitro Antioxidant and Antimicrobial Activities of Some Novel 2-Methoxy-4-[(3-substitue-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azomethine]phenyl 2-methylbenzoate Derivatives
Yazarlar (7)
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
Osman Kutanis
Gül Özdemir
Prof. Dr. Murat BEYTUR Kafkas Üniversitesi, Türkiye
Savaş Kara
Prof. Dr. Özlem Gürsoy Kol Kafkas Üniversitesi, Türkiye
Prof. Dr. Muzaffer ALKAN Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Research Journal of Pharmaceutical, Biological and Chemical Sciences | ||
| Dergi ISSN | 0975-8585 Dergi Bilgileri (2018) | ||
| Dergi Tarandığı Indeksler | Emerging Sources Citation Index - ESCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2018 |
| Cilt / Sayı / Sayfa | 9 / 4 / 501–512 | DOI | – |
| UAK Araştırma Alanları |
Fen Bilgisi Eğitimi
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| Özet |
| In the present study, nine novel 2-methoxy-4-[(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azonnethine)phenyl 2-methylbenzoates (4a-i) were synthesized from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2a-i) with 3-(2-methylbenzoxy)-4-methoxybenzaldehyde (3) by using triethylamine. Then, the acetylation reactions of compounds 4a-e and 4g were investigated and 5 type compounds synthesized. The structures of fifteen new compounds were established from IR, H-1 NMR, C-13 NMR, UV and mass spectral data. In addition, the synthesized new 4 and 5 type compounds were analyzed for their in vitro potential antioxidant activities in three different methods; including 1,1-diphhenlyl-2-picrylhydrazyl free radical (DPPH.) scavenging, reducing activity by Fe+3 - Fe+2 transformation and ferrous metal (Fe+2) chelating activities. Furthermore, the synthesized compounds were … |
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BM Sürdürülebilir Kalkınma Amaçları
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