Synthesis Potentiometric Titrations and Antioxidant Activities os Some 4 Acylamino 4 5 dihydro 1H 1 2 4 triazol 5 one Derivatives
Yazarlar (7)
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Asian Journal of Chem | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2008 |
| Cilt / Sayı / Sayfa | – / 20 / 5311–5321 | DOI | – |
| Özet |
| Five novel 3-alkyl-4-cinnamoylamino-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (1) with cinnamoyl chloride and characterized by elemental analyses and IR, 1H NMR, 13C NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, t-butyl alcohol, acetonitrile and N, N-dimethylformamide and the half-neutralization potential values and the corresponding pKa values were determined for all cases. In addition, these new compounds (except compound 2a) and five recently reported 3-alkyl-4-isobutyrylamino-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (3) were screened for their antioxidant activities. |
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