Synthesis and Acidic Properties of Novel 3 Methyl 4 2 amino 1 3 4 thiadiazol 5 il thioacetylamino 4 5 dihydro 1H 1 2 4 triazol 5 one
Yazarlar (3)
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
Prof. Dr. Muzaffer ALKAN Kafkas Üniversitesi, Türkiye
Prof. Dr. Şule Bahçeci Trabzon Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molbank | ||
| Dergi ISSN | 1422-8599 Dergi Bilgileri (2006) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2006 |
| Cilt / Sayı / Sayfa | – / 1 / 462– | DOI | – |
| Makale Linki | https://www.proquest.com/openview/928da1460c137ae5c813bfb31b2996be/1?pq-origsite=gscholar&cbl=2032356 | ||
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Fen Bilgisi Eğitimi
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| Özet |
| A number of studies involving the determination of pKa values of some 4, 5-dihydro-1H-1, 2, 4-triazol-5-one derivatives in non-aqueous solvents has been revealed [1-3]. 3-Methyl-4-[(2-amino-1, 3, 4-thiadiazol-5-il)-thioacetylamino]-4, 5-dihydro-1H-1, 2, 4-triazol-5-one 3 was synthesized from the reaction of 3-methyl-4-chloroacetylamino-4, 5-dihydro-1H-1, 2, 4-triazol-5-one 1 with 2-amino-5-mercapto-1, 3, 4-thiadiazole 2. Moreover, the synthesized compound 3 was titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in three non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol and,-dimethylformamide to determine pKa values. For compound 3, the half-neutralization potentials (HNP) and the corresponding pKa values were determined in the three non-aqueous solvents mentioned above. The starting compound 1 was prepared according to literature [2, 4].3-Methyl-4 … |
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| Google Scholar | 1 |