Synthesis and Acidic Properties of Some New Potential Biologically active 4 Acylamino 4 5 dihydro 1H 1 2 4 triazol 5 one Derivatives
Yazarlar (6)
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
Prof. Dr. Muzaffer ALKAN Kafkas Üniversitesi, Türkiye
Doç. Dr. Zafer OCAK Kafkas Üniversitesi, Türkiye
Prof. Dr. Şule Bahçeci Trabzon Üniversitesi, Türkiye
Prof. Dr. Miraç Ocak Karadeniz Teknik Üniversitesi, Türkiye
Mustafa Özdemir
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Indian J. of Chem | ||
| Dergi ISSN | 0019-5103 | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2004 |
| Cilt / Sayı / Sayfa | – / 43 / 1527–1531 | DOI | – |
| UAK Araştırma Alanları |
Fen Bilgisi Eğitimi
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| Özet |
| 3-Alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2 react with acyl halides such as chloroacetyl chloride, dichloroacetyl chloride and isobutyryl chloride to give the corresponding 3-alkyl(aryl)-4-chloroacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones 3, 3-alkyl(aryl)-4-(dichloroacetylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 4 and 3-alkyl(aryl)-4-isobutyrylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones 5, respectively. The newly synthesized compounds have been characterized by elemental analyses, IR, H-1 NMR, C-13 NMR and UV spectral data. In addition, all ten new compounds are titrated potentiometrically with tetrabutylammonium hydroxide in four different non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide. The half neutralization potential values and the corresponding pK(a) values have been determined for all the cases. Thus, the effects of solvents … |
| Anahtar Kelimeler |
