Synthesis, antioxidant and antimicrobial properties of new mannich bases containing 1,2,4-triazole moiety
Yazarlar (5)
Prof. Dr. Özlem Gürsoy Kol Kafkas Üniversitesi, Türkiye
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
Doç. Dr. Sevda MANAP Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Fevzi AYTEMİZ Kafkas Üniversitesi, Türkiye
Prof. Dr. Muzaffer ALKAN Kafkas Üniversitesi, Türkiye
| Bildiri Türü | Tebliğ/Bildiri | Bildiri Dili | İngilizce |
| Bildiri Alt Türü | Özet Metin Olarak Yayınlanan Tebliğ (Uluslararası Kongre/Sempozyum) | ||
| Bildiri Niteliği | Alanında Hakemli Uluslararası Kongre/Sempozyum | ||
| Kongre Adı | 3rd International Conference on New Trends in Chemistry (ICNTC 2017) | ||
| Kongre Tarihi | 28-04-2017 / 30-04-2017 | ||
| Basıldığı Ülke | Finlandiya | Basıldığı Şehir | Helsinki |
| Bildiri Linki | http://www.icntcconference.com/ | ||
| UAK Araştırma Alanları |
Fen Bilgisi Eğitimi
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| Özet |
| Triazoles are heterocyclic compounds that contain three nitrogen atoms. 1, 2, 4-Triazole and 4, 5-dihydro-1H-1, 2, 4-triazol-5-one derivatives are reported to possess a broad spectrum of biological activities such as analgesic, antibacterial, antioxidant and antiparasitic properties [1-3]. Considering about the development of new hetero moieties by combining potential biological active scaffolds, an attempt was made here to obtain 1, 2, 4-triazoles bearing morpholine ring and to evaluate their antioxidant activity.In this regard, eight new 1-(morpholine-4-yl-methyl)-3-alkyl (aryl)-4-(4-methylthiobenzylidenamino)-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (2) and seven new 1-(2, 6-dimethylmorpholine-4-yl-methyl)-3-alkyl (aryl)-4-(4-methylthiobenzylidenamino)-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (3) were synthesized by the reactions of 3-alkyl (aryl)-4-(4-methylthiobenzylidenamino)-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (1) with formaldehyde and morpholine, 2, 6-dimethylmorpholine, respectively. 3-alkyl (aryl)-4-(4-methylthiobenzylidenamino)-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (1) were synthesized according to literature [4]. The titled compounds were characterized by IR, 1H NMR and 13C NMR spectral data. |
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