Low sCD163/TWEAK Ratio at First Day After Acute Myocardial Infarction Associated with Adverse Cardiac Remodeling in Non-Elderly Patients.
Yazarlar (6)
Mehmet Sait Altıntaş
Türkiye
Türkiye
Doç. Dr. Nilnur EYERCİ Kafkas Üniversitesi, Türkiye
Murak Gök
Emrullah Kızıltunç Türkiye
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Özgün Makale
(Diğer hakemli uluslarası dergilerde yayınlanan tam makale)
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| Dergi Adı | Kardiologiia | ||
| Dergi ISSN | 0022-9040 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | RSCI | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2022 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 30-10-2022 |
| Cilt / Sayı / Sayfa | 62 / 10 / 49– | DOI | 10.18087/cardio.2022.10.n2155 |
| Makale Linki | https://lib.ossn.ru/jour/article/view/2155 | ||
| Özet |
| Aim In this study, we aimed to investigate the role of sCD163 / tumor necrosis factor-like weak apoptosis-inducing (TWEAK) ratio in cardiac remodeling in non-elderly patients diagnosed with first acute myocardial infarction (MI).Material and Methods Forty-four patients (age ranges: 40–64 years) diagnosed with first-time acute ST-elevation MI in the emergency department were evaluated with cardiac magnetic resonance (CMR) imaging. Adverse remodeling (AR) was defined the increases of left ventricular end-diastolic volume by ≥12 % by CMR at 6‑month post-MI TWEAK and sCD163 were measured at the first day (baseline), 2 weeks and 6 weeks post-MI.Results The average age of patients included in the study was 53.6±5.1 years. AR was detected in 18 patients at the 6 months post-MI. At the first day post-MI, median sCD163 concentration (116 069 vs 86 394 pg / mL, p=0.040) and median TWEAK concentration (759.4 vs 220.1 pg / mL, p<0.001) were higher in AR group compared to group without AR (the non-AR group), median sCD163 / TWEAK ratio (101.4 vs. 406.8; p<0.001) was lower. At the first day post-MI, concentrations of TWEAK and sCD163 showed a positive correlation in AR group and group without AR s. At 2 weeks post-MI, positive correlation continued in the non-AR group, but no significant correlation was found in the AR group. At the first day post-MI, sCD163 / TWEAK ratio was higher diagnostic performance compared to TWEAK and sCD163.Conclusion In the early phase post-MI, the relationship between sCD163 – TWEAK may have an important role in AR pathogenesis. A lower sCD163 / TWEAK ratio on the first day after MI was associated with an increase in left ventricular end-diastolic volume after 6 months of follow-up. |
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BM Sürdürülebilir Kalkınma Amaçları
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