VDR gene FokI polymorphism as a poor prognostic factor for papillary thyroid cancer/title
Yazarlar (9)
PROFESÖR Selvihan Beysel Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye
Doç. Dr. Nilnur EYERCİ Kafkas Üniversitesi, Türkiye
Ferda Alparslan Pinarli
Muhammed Kizilgul
Seyfullah Kan
Süleyman Demirel Üniversitesi, Türkiye
Süleyman Demirel Üniversitesi, Türkiye
Erman Çakal
Sağlık Bilimleri Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
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Özgün Makale
(Diğer hakemli uluslarası dergilerde yayınlanan tam makale)
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| Dergi Adı | Tumor Biology | ||
| Dergi ISSN | 1010-4283 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | IM: Index Medicus | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-11-2018 |
| Cilt / Sayı / Sayfa | 40 / 11 / 2147483647– | DOI | 10.1177/1010428318811766 |
| Makale Linki | http://journals.sagepub.com/doi/10.1177/1010428318811766 | ||
| Özet |
| This is the first study to investigate the effect of vitamin D receptor ( VDR) gene single-nucleotide polymorphisms on the clinicopathologic features of papillary thyroid cancer in Turkey. A total of 165 patients with papillary thyroid cancer and 172 controls were included in this case–control study. VDR gene single-nucleotide polymorphisms FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) were evaluated using reverse-transcription polymerase chain reaction. VDR gene polymorphisms BsmI, ApaI, and TaqI did not differ between the papillary thyroid cancer group and control group (p > 0.05, each). BsmI, ApaI, and TaqI were not associated with papillary thyroid cancer risk. The VDR gene FokI CT/TT genotype was associated with an increased papillary thyroid cancer risk (CT vs CC: odds ratio = 1.71, 95% confidence interval = 1.15–2.76, p = 0.028; TT vs CC: odds ratio = 2.44, 95% confidence interval = 1.29–4.62, p = 0.005; CT/TT vs CC: odds ratio = 1.88, 95% confidence interval = 1.20–2.96, p = 0.006; CT/CC vs TT: odds ratio = 1.80, 95% confidence interval = 1.05–3.20, p = 0.041). VDR gene polymorphisms were not in linkage disequilibrium. The FokI TT genotype was associated with having T3 and T4, stage III/IV, extra-thyroidal invasion. The FokI CT/TT or TT genotype was associated with developing N1 status, multifocality, tumor size ≥10 mm, and treatment with radioiodine therapy. Persistence/recurrence did not differ between the FokI genotypes. Carriers of the FokI T allele were at an increased risk of more advanced tumor-node-metastasis stage, greater tumor size, multifocality, and extra-thyroidal invasion of papillary thyroid cancer compared with the CC genotype. VDR gene FokI T allele and TT genotype correlated with aggressiveness of papillary thyroid cancer; thus, FokI could be useful as a poor prognostic factor to assess the high risk of papillary thyroid cancer. |
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BM Sürdürülebilir Kalkınma Amaçları
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