Association of MICA Alleles and Human Leukocyte Antigen B in Turkish Patients Diagnosed With Behçet’xxs Disease
Yazarlar (4)
Doç. Dr. Nilnur EYERCİ Kafkas Üniversitesi, Türkiye
Eda Balkan Atatürk Üniversitesi, Türkiye
Necmettin Akdeniz
İstanbul Medeniyet Üniversitesi, Türkiye
İstanbul Medeniyet Üniversitesi, Türkiye
Sadullah Keleş Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Archives of Rheumatology | ||
| Dergi ISSN | 2148-5046 | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2018 |
| Cilt / Sayı / Sayfa | 33 / 3 / 352–357 | DOI | 10.5606/ArchRheumatol.2018.6704 |
| Özet |
| Objectives: This study aims to investigate whether or not MHC class I polypeptide-related sequence A (MICA) polymorphisms are associated with the susceptibility to Behçet’s disease (BD) in a Turkish population. Patients and methods: The study included 38 Turkish BD patients (20 males, 18 females; mean age 34±10.9 years) and 51 ethnically matched healthy controls (30 males, 21 females; mean age 36±12.8 years). MICA and human leukocyte antigen B (HLA-B) alleles were determined in all subjects by using the Luminex technology. LABType® sequence-specific oligonucleotide (SSO) MICA test (One Lambda) and SSO B locus tests (Gene-Probe) were used for the typing studies. Results: A total of 16 MICA alleles were found in BD patients as well as in control subjects. The gene frequency of MICA*006 was significantly higher in the BD patients compared to controls (14.5% vs. 0.9%; odds ratio [OR]: 17.092 95% confidence interval [CI] [2.155~135.554]; p<0.05). When haplotypes were evaluated, an association was found between the haplotypes HLA-B*51-MICA*006 (11.8% and 0.9%; OR: 13.567 95% CI [1.679~109.577]; p<0.001) and HLA-B*51-MICA*009 (27.6% and 13.7%; OR: 2.4 95% CI [1.127~5.109]; p<0.05). Frequencies of HLA-B*49-MICA*004 (0% and 6.8%) and HLA-B*52-MICA*009 (0% and 10.7%) were significantly higher in controls compared to BD patients (p<0.05). Conclusion: Our study shows that the MICA*006 (MICA-A6) and the MICA*009 alleles are associated with BD susceptibility in HLA-B*51 positive Turkish population, particularly in HLA-B*51 patients with MICA*006, which might be considered as a diagnostic biomarker for BD in the future. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |