Comparison of non-invasive tests with invasive tests in the diagnosis of celiac disease
Yazarlar (8)
Yasemin Derya Gülseren
Necmettin Erbakan Üniversitesi, Türkiye
Necmettin Erbakan Üniversitesi, Türkiye
Mihriban Yücel
DOKTOR ÖĞRETİM ÜYESİ Zuhal Dağ Fırat Üniversitesi, Türkiye
Doç. Dr. Nilnur EYERCİ Kafkas Üniversitesi, Türkiye
Rukiye Berkem
Levent Filik
Sağlık Bilimleri Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
Muzaffer Çaydere
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | JOURNAL OF CLINICAL LABORATORY ANALYSIS (Q3) | ||
| Dergi ISSN | 0887-8013 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2019 |
| Kabul Tarihi | 18-10-2018 | Yayınlanma Tarihi | 21-11-2018 |
| Cilt / Sayı / Sayfa | – / 3 / 22722– | DOI | 10.1002/jcla.22722 |
| Makale Linki | http://doi.wiley.com/10.1002/jcla.22722 | ||
| Özet |
| Background/AimsToday, invasive diagnostic tests are necessary for definite diagnosis of adult celiac disease (CD). However, in selected children patients, the need for invasive tests is ceased. In this study, we evaluated adult patients according to the ESPGHAN (European Pediatric Gastroenterology Hepatology and Nutrition Society) criteria.MethodsThirty‐nine patients (aged 17‐66) with symptoms of CD were included. Serum samples were tested for total IgA, tTG‐IgA (antitissue transglutaminase), tTG‐IgG, DGP‐IgA (antideamidated gliadin peptide), DGP‐IgG, and EMA (endomysial antibodies). HLA‐DQ typing was studied with PCR‐SSP (sequence‐specific primers) method. Biopsy samples were evaluated according to Marsh scoring.ResultsIn CD patients, 71.4% (15/21) of the patients were diagnosed without biopsy according to the EPSGHAN criteria but when ESPGHAN's IgA tTG threshold value for children was taken into consideration (>200 IU/mL), the sensitivity decreased to 81%. Celiac disease diagnosed and control groups were compared in terms of HLA tissue types. DQ2.5 homozygous or DQ2.5/DQ2.2 was significantly higher in CD group, and DQ2‐ or DQ8‐negative HLA tissue type was significantly higher in control group.ConclusionWhen serological tests, HLA typing, and clinical symptoms are all in favor of CD, biopsy may not be performed in selected adult CD patients. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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