Immunohistochemically Evaluation of PCNA and MMP-9 Expressions in Different Types of Canine Mammary Carcinomas
Yazarlar (7)
Doç. Dr. Emin KARAKURT Kafkas Üniversitesi, Türkiye
Prof. Dr. Mushap KURU Kafkas Üniversitesi, Türkiye
Prof. Dr. Serpil DAĞ Kafkas Üniversitesi, Türkiye
Prof. Dr. Enver BEYTUT Kafkas Üniversitesi, Türkiye
Hasan Oral
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Hilmi NUHOĞLU Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ayfer YILDIZ UYSAL Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | Dicle Üniversitesi Veteriner Fakültesi Dergisi | ||
| Dergi ISSN | 1307-9972 | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | Türkçe | Basım Tarihi | 12-2020 |
| Kabul Tarihi | 14-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 13 / 2 / 119–124 | DOI | 10.47027/duvetfd.794571 |
| Makale Linki | https://www.researchgate.net/publication/346759409_Immunohistochemically_Evaluation_of_PCNA_and_MMP-9_Expressions_in_Different_Types_of_Canine_Mammary_Carcinomas | ||
| Özet |
| The aim of this study was to evaluate reveal whether there is a significant relationship between cell proliferation and invasion-metastasis capacity in various mammary adenocarcinoma subtypes observed in dogs, by means of immunohistochemical markers such as PCNA and MMP-9. The material of this study was composed of tissue samples of mammary carcinomas taken from 6 Kangal and 4 Setter dogs with an average age of 8.4 years brought to our department between 2012-2020 years. Tissue samples from dogs were fixed in 10 % buffered formaldehyde solution. After routine tissue procedures, 5 μm thick sections were taken from paraffin blocks prepared for Hematoxylin and Eosin staining. Sections were examined under light microscope to determine the cancer patterns. Avidin-Biotin Peroxidase method was used as immunohistochemical method. 4 of 10 mammary carcinoma cases were classified as intraductal papillary carcinoma, 4 as carcinoma mixed, 1 as solid carcinoma and 1 as tubular carcinoma. We found the highest mean number of PCNA and MMP-9 positive cells in solid subtype. In conclusion, we thought that a positive relationship between cell proliferation and invasion and metastasis capacity under the solid subtype. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |