Synthesis, in vitro antioxidant activity, and physicochemical properties of novel 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives
Yazarlar (5)
Prof. Dr. Haydar YÜKSEK Kafkas Üniversitesi, Türkiye
Ebru Koca Kafkas Üniversitesi, Türkiye
Özlem Gürsoy Kol Kafkas Üniversitesi, Türkiye
Doç. Dr. Onur AKYILDIRIM Kafkas Üniversitesi, Türkiye
Mustafa Çelebier Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Liquids | ||
| Dergi ISSN | 0167-7322 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2015 |
| Cilt / Sayı / Sayfa | 206 / 1 / 359–366 | DOI | 10.1016/j.molliq.2015.02.038 |
| Özet |
| In this study, eight new 3-alkyl(aryl)-4-[4-(4-methylbenzoxy)benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-one (4) compounds were synthesized by the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) with 4-(4-methylbenzoxy)benzaldehyde (1). The eight compounds were characterized using IR, 1H NMR, 13C NMR, and UV spectral data. In addition, the synthesized compounds were analyzed for their potential in vitro antioxidant activities, including reducing power, free radical scavenging and metal chelating activity. These antioxidant activities were compared to those from standard antioxidants, such as EDTA, BHA, BHT and α-tocopherol. Moreover, compounds 4 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, acetone and N,N-dimethylformamide). Thus, the half-neutralization potential values and the … |
| Anahtar Kelimeler |
| 1,2,4-Triazol-5-one | Acylation | Antioxidant activity | Physicochemical properties | Schiff base | Syntheses |
Science Direct
Synthesis, in vitro antioxidant activity, and physicochemical properties of novel 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 32 |
| Web of Science | 22 |
| Scopus | 21 |