Ratlarda Lipopolisakkarit İndüklü Deneysel Endotoksemi Modelinde Adenozin Deaminaz, Nitrik Oksit ve Karaciğer Enzimleri Üzerine Laktoferrinin Koruyucu Etkisi
Yazarlar (4)
Doç. Dr. Canan GÜLMEZ SAMSA Iğdır Üniversitesi, Türkiye
Doç. Dr. Kezban YILDIZ DALGINLI Kafkas Üniversitesi, Türkiye
Prof. Dr. Emine ATAKİŞİ Kafkas Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Kafkas Universitesi Veteriner Fakultesi Dergisi | ||
| Dergi ISSN | 1300-6045 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2020 |
| Cilt / Sayı / Sayfa | 26 / 6 / 801–806 | DOI | – |
| Makale Linki | http://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2750.pdf | ||
| UAK Araştırma Alanları |
Veteriner Biyokimyası
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| Özet |
| In this study, the effect of lactoferrin (LF) on adenosine deaminase (ADA) activity, nitric oxide (NO) and liver enzyme levels were investigated in lipopolysaccharide (LPS)-induced experimental endotoxemia model in rats. Forty Sprague Dawley female rats were divided into four groups as control, LF (20 mg/kg, ip), LPS (20 µg/kg, ip)(E. coli type 0111: B4) and LF+ LPS (20 mg/kg LF+ 20 µg/kg LPS, ip). For a week, LF was given daily, while LPS was given a single dose. Liver adenosine deaminase, nitric oxide and liver enzymes (aspartate aminotransferase'AST', alanine aminotransferase'ALT'and gamma glutamyltranspeptidase'GGT') levels of animals sacrificed six hours after LPS injection were determined. It was found that ADA activity, considered to be a marker of cellular immunity, and NO levels increased in LPS-induced endotoxemia and LF supplementation decreased these levels significantly (P< 0.001). There … |
| Anahtar Kelimeler |
