Hepatoprotective effect of l carnitine against acute acetaminophen toxicity in mice
Yazarlar (5)
Yapar Kürsat
Asım Kart
Prof. Dr. Mahmut KARAPEHLİVAN Kafkas Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ Kafkas Üniversitesi, Türkiye
Mehmet Citil
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | ||
| Dergi ISSN | 0940-2993 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2007 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-10-2007 |
| Cilt / Sayı / Sayfa | 59 / 2 / 121–128 | DOI | 10.1016/j.etp.2007.02.009 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0940299307000280 | ||
| UAK Araştırma Alanları |
Veteriner Biyokimyası
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| Özet |
| l-carnitine is a cofactor in the transfer of long-chain fatty acid allowing the β-oxidation of fatty acid in the mitochondria. It is also a known antioxidant with protective effects against lipid peroxidation. In this study, hepatoprotective effect of l-carnitine was investigated against acetaminophen (AA)-induced liver toxicity where mitochondrial dysfunction and oxidative stress are thought to be involved in AA hepatotoxicity. Sixty-four Balb/C mice were divided into eight groups. Mice were dosed with single-AA injection (500mg/kg via the intra peritoneal route) with or without l-carnitine (500mg/kg for 5 days starting 5 days before AA injection via intra peritoneal route) and sampled at 4, 8 and 24h following AA injection. AA increased serum AST, ALT, total sialic acid (TSA) and MDA as well as tissue TSA and MDA levels significantly with the highest increase observed at 4h, but there was a decrease in blood and tissue GSH level … |
| Anahtar Kelimeler |
| l-carnitine | acetaminophen | sialic acid | hepatoprotection | oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 84 |
| Google Scholar | 175 |