| Yazarlar (6) |
Hidayet Metin Erdoğan
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Mahmut KARAPEHLİVAN
Kafkas Üniversitesi, Türkiye |
|
Mehmet Çitil
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Onur ATAKİŞİ
Kafkas Üniversitesi, Türkiye |
|
Erdoğan Uzlu
Kafkas Üniversitesi, Türkiye |
|
Ahmet Ünver
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
| Özet |
| This study was designed to disclose some indicators of oxidative stress and inflammation in natural cases of bovine leptospirosis. For this purpose, 12 bulls exhibiting clinical signs of leptospirosis and 10 healthy bulls were used. Animals were subjected to thorough clinical examination and the clinical signs were recorded. All animals were blood sampled in order to determine serum total sialic acid (TSA), lipid bound sialic acid (LBSA), malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), uric acid (UA), total protein (TP), albumin and glucose. Urine samples were collected from each animal and examined under dark-field microscope to observe spirochetes. Diseased animals exhibited clinical signs suggesting leptospirosis and the diagnosis was supported by positive dark-field microscope examination. Mean TSA (mmol/L), LBSA (mmol/L), TP (g/dl), albumin (g/dl), glucose (mg/dl), MDA (micromol/L), GSH (mg/dl), NO (nmol/ml), and UA (mg/L) levels were 1.63 +/- 0.02, 0.40 +/- 0.10, 7.18 +/- 0.24, 3.23 +/- 0.5, 64.96 +/- 1.88, 5.71 +/- 0.11, 78.68 +/- 0.72, 7.94 +/- 0.34, and 8.75 +/- 0.41 in healthy bulls, and 2.50 +/- 0.05, 0.70 +/- 0.2, 9.27 +/- 0.17, 2.55 +/- 0.62, 107.93 +/- 2.52, 8.82 +/- 0.14, 47.85 +/- 1.85, 14.57 +/- 0.63 and 15.85 +/- 0.80 in leptospirosis cases, respectively. The differences between the two groups were statistically significant (P < 0.001). Increased TSA, LBSA, MDA, NO, UA, TP, glucose and decreased GSH and albumin concentrations were suggestive of inflammation and oxidative stress in diseased bulls. The results obtained may suggest that oxidative damage along with other mechanisms might have taken part in the pathogenesis of bovine leptospirosis and further detailed studies are needed to fully understand the mechanism(s) of the disease. |
| Anahtar Kelimeler |
| cattle | leptospirosis | sialic acid | oxidative stress |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | VETERINARY RESEARCH COMMUNICATIONS |
| Dergi ISSN | 0165-7380 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2008 |
| Cilt No | 32 |
| Sayı | 4 |
| Sayfalar | 333 / 339 |
| Doi Numarası | 10.1007/s11259-008-9036-z |
| Makale Linki | http://link.springer.com/10.1007/s11259-008-9036-z |
| Atıf Sayıları | |
| WoS | 25 |
