Ameliorative Effect of Omega-3 in Carbon Tetrachloride Toxicity
Yazarlar (6)
Prof. Dr. Musa Karaman Balıkesir Üniversitesi, Türkiye
Prof. Dr. Hasan Özen Kafkas Üniversitesi, Türkiye
Prof. Dr. Serpil DAĞ Kafkas Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ Kafkas Üniversitesi, Türkiye
Gülşen Çığşar
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Doç. Dr. Oktay Kaya Trakya Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI | ||
| Dergi ISSN | 1300-6045 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2016 |
| Cilt / Sayı / Sayfa | 23 / 1 / 77–85 | DOI | 10.9775/kvfd.2016.15862 |
| Makale Linki | https://doaj.org/article/1bf01cfebe4849998a6b6e0fbc763da0 | ||
| UAK Araştırma Alanları |
Veteriner Biyokimyası
|
||
| Özet |
| Omega-3 is a polyunsaturated fatty acid known to have immunomodulatory functions. In the present study, ameliorative potential of omega-3 in experimental carbon tetrachloride (CCl4) toxicity was investigated. Total of 40 adult male Wistar albino rats were allocated into five groups and were subcutaneously given once every two days for 6 weeks the followings: Group 1 (Control): 0.5 ml/kg serum physiologic, Group 2 (Omega): 0.5 g/kg omega-3, Group 3 (Vehicle): 0.5 ml/kg pure olive oil, Group 4 (CCl4): 0.5 ml/kg CCl4, Group 5 (CCl4+ Omega): 0.5 ml/kg CCl4 plus 0.5 g/kg omega-3. At the end of the treatments, blood samples were collected and necropsy was performed for collection of liver tissues. Serum AST, AlT, GGT, TAC, TOC, triglyceride, and visfatin levels were detected. liver morphology and immunoreactivities against TGF-α, TGF-β, PPAR-α, and PPAR-γ were assessed. Serum AST, AlT, GGT, and TOC levels significantly increased while TAC level decreased in CCl4 given animals as compared to the control group. No significant changes were observed in triglyceride and visfatin levels. Immunohistochemical staining revealed increased TGF-α and TGF-β expressions and decreased PPAR-α and PPAR-γ expressions in liver of CCl4 given animals. Omega-3 supplementation has prominent effects in correcting the biochemical and immunohistochemical parameters studied as well as the tissue morphology. The results of the investigation indicated that omega-3 has ameliorative effects on the oxidative tissue degeneration and inflammatory processes induced by CCl4 treatment in rats. |
| Anahtar Kelimeler |
| CCl4 | Omega-3 | TGF-alpha | TGF-beta | PPAR-alpha | PPAR-gamma |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Google Scholar | 11 |