NITRIC OXIDE LEVELS AND OXIDANT ANTIOXIDANT CAPACITIES IN PATIENTS WITH BRUCELLOSIS
Yazarlar (4)
Berrin Pancarcı
Prof. Dr. Ahmet Ünver Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Prof. Dr. Yeliz Çetinkol Ordu Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ACTA MEDICA MEDITERRANEA | ||
| Dergi ISSN | 0393-6384 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2016 |
| Cilt / Sayı / Sayfa | 32 / 1 / 69–73 | DOI | 10.19193/0393-6384_2016_1_10 |
| UAK Araştırma Alanları |
Tıbbi Biyokimya
|
||
| Özet |
| Introduction This study aimed to investigate relationships among serum nitric oxide (NO) concentrations, total oxidant-antioxidant capacities (TOC-TAC), serum C-Reactive Protein (CRP), Aspartate Aminotransferase (AST), Alanin Aminotransferase (ALT) and hematological parameters in Brucella seropositive (serum samples positive for Brucella) and seronegative (serum samples negative for Brucella) human serum samples. Materials and methods Eighty positive and 20 negative human sera to Brucella Serum Tube Agglutination Test were used for determination of NO, TOC-TAC, CRP, AST, ALT. Results Serum TOC concentrations were significantly (P<0.01) higher in Brucella seropositive titers compared to Brucella seronegative serum samples regardless of titers. However, there was no difference among different seropositive titers for serum TOC concentrations. In contrast, no effect of Brucella antibody titers on serum NO, TAC, CRP, AST and ALT levels was proved. However, AST concentration tended to be (P<0.07) higher at 1/640 titer. While Brucella antibody titers decreased leukocyte (P<0.05) and increased erythrocyte (P<0.05) counts at 1/640 titers with no change at 11160 and 1/320 titers, no effect of Brucella antibody titers was detected on thrombocyte counts. There was a positive correlation between Brucella antibody titers and TOC (r=0,44; P<0,01), AST (r=0,23; P=0,05) levels and erythrocyte counts (r=0,32; P<0,01); whereas, there was a negative correlation between Brucella antibody titers and leukocyte counts (r=-0.32; P<0,01). Conclusion The increase in TOC levels and steady state levels of TAC could reveal that antioxidant … |
| Anahtar Kelimeler |
| Brucellosis | nitric oxide | oxidant and antioxidant capacity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Google Scholar | 2 |