The effect of different doses of metamisole sodium on serum enzymeactivities and tissue oxidant levels in liver and kidney in mice
Yazarlar (6)
Yapar Kürşat
Prof. Dr. Emine ATAKİŞİ Kafkas Üniversitesi, Türkiye
Prof. Dr. Erdoğan Uzlu Kafkas Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ Kafkas Üniversitesi, Türkiye
Prof. Dr. Mehmet Çitil Kafkas Üniversitesi, Türkiye
Prof. Dr. Hidayet Metin Erdoğan Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI | ||
| Dergi ISSN | 1300-6045 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2007 |
| Cilt / Sayı / Sayfa | 13 / 2 / 121–125 | DOI | 10.5555/20083090216 |
| UAK Araştırma Alanları |
Veteriner Biyokimyası
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| Özet |
| Metamisole sodium (MS), a pyrosilone derivate, is widely used non-opioid analgesic in veterinary medicine. This study was conducted to evaluate the effect of different doses of metamizole sodium on serum urea, creatine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phophatase (ALP) activities and tissue malondialdehyde (MDA) and reduced glutathione (GSH) level in liver and kidney of 32 Swiss Albino mice. The animals were divided into four equal groups. One group served as the control, while groups 1, 2 and 3 received 20, 50 and 100 mg/kg MS intramuscularly for seven days, respectively. After a seven-day injection, blood and tissue samples were collected from the mice. Serum samples were examined for the determination of BUN, creatine, ALT, AST and ALP, while tissue samples were evaluated for MDA and GSH levels. Results revealed that the high dose group (100 … |
| Anahtar Kelimeler |
| metamisole sodium | enzyme | MDA | GSH | liver | kidney |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Google Scholar | 3 |