Effect of L carnitine on plasma slalic acid MDA and blood GSH levels in doxorubicine administered rabbits
Yazarlar (6)
Prof. Dr. Mahmut KARAPEHLİVAN Kafkas Üniversitesi, Türkiye
Prof. Dr. Erdoğan Uzlu Kafkas Üniversitesi, Türkiye
Prof. Dr. Hidayet Metin Erdoğan Kafkas Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ Kafkas Üniversitesi, Türkiye
Prof. Dr. Metehan Uzun Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Prof. Dr. Mehmet Çitil Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI | ||
| Dergi ISSN | 1300-6045 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2007 |
| Cilt / Sayı / Sayfa | 13 / 2 / 155–160 | DOI | 10.5555/20083090222 |
| UAK Araştırma Alanları |
Veteriner Biyokimyası
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| Özet |
| The aim of this study was to determine the protective effect of L-carnitine (LCAR) against the toxicity of doxorubicin (DOX) an antineoplastic drug, treatment dose on plasma sialic acid (SA), malondialdehyde (MDA) and reduced glutathione (GSH) levels. 21 healthy New Zealand rabbits were divided to Group I (n=8) 0.6 mg/kg DOX; Group II (n=7) 0.6 mg/kg DOX with 1000 mg/kg LCAR; and Group III (n=6) 1000 mg/kg Dox were administered intraperitoneally for six days. Blood samples were obtained after 2 h of administration. SA levels in Groups I and II significantly increased (P<0.001) after application than before administration, but SA levels in Group III decreased (P<0.001). GSH level in Group I was (P<0.05) lower on day three than on day one. GSH levels in Group III significantly increased (P<0.05) from day two of administration. MDA levels on days three, four, five and six in Group I increased (P<0.001 … |
| Anahtar Kelimeler |
| doxorubicin | rabbit | sialic acid | MDA | GSH |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Google Scholar | 3 |