| Yazarlar |
Nüket Bilgen
Ankara Üniversitesi, Türkiye |
|
Merve Bişkin Türkmen
Türkiye |
|
Bengi Çınar Kul
Ankara Üniversitesi, Türkiye |
|
Sevim Isparta
Türkiye |
|
Yusuf Şen
Türkiye |
|
Mustafa Yenal Akkurt
Ankara Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Özge Şebnem ÇILDIR
Kafkas Üniversitesi, Türkiye |
|
Zeynep Bars
Türkiye |
| Özet |
| Polycystic kidney disease (PKD) is one of the most common hereditary diseases in cats, with high prevalence in Persian and Persian-related cats. PKD is caused mainly by an inherited autosomal dominant (AD) mutation, and animals may be asymptomatic for years. We screened 16 cats from various breeds exhibiting a renal abnormality by ultrasound examination and genotyped them for the c.10063C>A transversion on exon 29 of the polycystin-1 () gene, by PCR-restriction fragment length polymorphism (PCR-RFLP). Among these cats, a Siamese nuclear family of 4 cats with ancestral hereditary renal failure were screened by whole-genome sequencing (WGS) to determine novel variations in genes associated with both AD and autosomal recessive PKD in humans. During the study period, one cat died as a result of renal failure and was forwarded for autopsy. Additionally, we screened 294 cats asymptomatic for renal disease (Angora, Van, Persian, Siamese, Scottish Fold, Exotic Shorthair, British Shorthair, and mixed breeds) to determine the prevalence of the mutation in cats in Turkey. Ten of the symptomatic and 2 of the asymptomatic cats carried the heterozygous C → A transversion, indicating a prevalence of 62.5% and 0.68%, respectively. In the WGS analysis of 4 cats in the Siamese nuclear family, novel variations were determined in the fibrocystin gene (), which was not compatible with dominant inheritance of PKD. |
| Anahtar Kelimeler |
| ADPKD | autosomal dominant | cats | hereditary disease | kidney | polycystic kidney disease |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION |
| Dergi ISSN | 1040-6387 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2020 |
| Cilt No | 32 |
| Sayı | 4 |
| Sayfalar | 549 / 555 |
| Doi Numarası | 10.1177/1040638720935433 |
| Makale Linki | https://journals.sagepub.com/doi/10.1177/1040638720935433 |
| Atıf Sayıları | |
| WoS | 4 |
