| Yazarlar |
Prof. Dr. Onur ATAKİŞİ
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Kezban YILDIZ DALGINLI
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Canan GÜLMEZ SAMSA
Iğdır Üniversitesi, Türkiye |
Rüya Kaya
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye |
|
Asım Kart
Burdur Mehmet Akif Ersoy Üniversitesi, Türkiye |
Prof. Dr. Emine ATAKİŞİ
Kafkas Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to investigate the effects of boric acid (BA) and borax (BX) on live weight and obesity associated molecules including leptin, L-carnitine, insulin-like growth factor 1 (IGF-I), and heat shock proteins 70 (HSP70) in rats fed with high-fat diet. A total of 60 rats were equally allocated as ND (normal diet), HF (high-fat diet), HF+BA, HF+BX, ND+BX, ND+BA. Body weight increases in HF+BA (85 g) and HF+BX (86 g) were significantly lower (p<0.05) compared to HF group (126 g). Boron treatment decreased serum L-carnitine level in high-fat diet (HF+BA 11.12 mg/L, HF+BX 10.51 mg/L, p<0.05) compared to HF group (15.57 mg/L), while no change was observed in groups ND+BA (7.55 mg/L) and ND+BX (7.57 mg/L) compared to group ND (8.29 mg/L). Neither BA nor BX supplementation in ND and HF groups altered the serum levels of HSP70 and leptin. BA and BX supplementation in rats fed HF resulted in a significant reduction in live weight. Boron compounds altered L-carnitine and IGF-1 levels in rats. These results indicate that boron compounds are beneficial in the treatment of obesity as well as in the prevention of high-fat diet-induced weight increase. Alterations in serum L-carnitine and IGF-1 levels in boron treated rats also indicate possible role of boron compounds in energy metabolism in response to high fat diet. |
| Anahtar Kelimeler |
| Boron compounds | L-Carnitine | Leptin | IGF-1 | HSP70 | High-fat diet |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH |
| Dergi ISSN | 0300-9831 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2020 |
| Cilt No | 90 |
| Sayı | 3 |
| Sayfalar | 221 / 227 |
| Doi Numarası | 10.1024/0300-9831/a000518 |
| Makale Linki | http://dx.doi.org/10.1024/0300-9831/a000518 |
| Atıf Sayıları | |
| WoS | 2 |
