| Yazarlar |
Kevser Tural
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye |
|
Zynep Bilgi
Türkiye |
|
E Kubat
Türkiye |
|
C S Ermutlu
Türkiye |
|
O Merhan
Türkiye |
|
Guvendi G Findik
Türkiye |
|
S A Kucuker
Türkiye |
| Özet |
| Betanin and copper sulphate have been previously indicated as beneficial agents for ischemia/reperfusion (I/R) as antioxidant compounds in various models. We investigated whether betanin and copper have any protective effects on the heart and lung against I/R injury in rats. Spraque-Dawley rats were assigned in groups: Sham (laparotomy only), control (I/R only), betanin treatment (100 mg/kg of betanin administered intraperitoneally (i.p.) 60 minutes before I/R) and copper sulfate treatment group (0.1 mg/kg/day copper sulfate i.p. for 7 days before I/R). Ischemia was induced by clamping the aorta between the left renal artery and aortic bifurcation for 45 minutes. After 48-hour reperfusion, the rats were sacrificed and heart/lung tissues were harvested. Malondialdehyde (MDA), myeloperoxidase (MPO), interleukin 6 (IL-6) levels were determined. Apoptosis was determined via TUNEL assay. MDA, MPO, IL-6 levels and apoptotic cells were significantly increased in the I/R group. In both treatment groups, MDA and MPO levels were decreased. IL-6 was significantly decreased in response to betanin administration in the heart, but not in the lung; copper had no effect in either area. The numbers of apoptotic cells were significantly decreased in both treatment groups. Betanin and copper may have protective effects on I/R injury in the heart and lung in rats (Fig. 6, Ref. 39). |
| Anahtar Kelimeler |
| ischemia reperfusion injury | betanin | copper | antiinflammation | antioxidant | rat |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY |
| Dergi ISSN | 0006-9248 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2020 |
| Cilt No | 121 |
| Sayı | 3 |
| Sayfalar | 211 / 217 |
| Doi Numarası | 10.4149/BLL_2020_032 |
| Makale Linki | http://www.elis.sk/index.php?page=shop.product_detailsflypage=flypage.tplproduct_id=6602category_id=158option=com_virtuemart |
| Atıf Sayıları | |
| WoS | 20 |
