The protective effect of betanin and copper on heart and lung in end‑organ ischemia reperfusion injury
Yazarlar (8)
Kevser Tural
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Prof. Dr. Özkan ÖZDEN Kafkas Üniversitesi, Türkiye
Zynep Bilgi Türkiye
E Kubat Türkiye
C S Ermutlu Türkiye
O Merhan Türkiye
Guvendi G Findik Türkiye
S A Kucuker Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | ||
| Dergi ISSN | 0006-9248 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2020 |
| Cilt / Sayı / Sayfa | 121 / 3 / 211–217 | DOI | 10.4149/BLL_2020_032 |
| Makale Linki | http://www.elis.sk/index.php?page=shop.product_detailsflypage=flypage.tplproduct_id=6602category_id=158option=com_virtuemart | ||
| Özet |
| Betanin and copper sulphate have been previously indicated as beneficial agents for ischemia/reperfusion (I/R) as antioxidant compounds in various models. We investigated whether betanin and copper have any protective effects on the heart and lung against I/R injury in rats. Spraque-Dawley rats were assigned in groups: Sham (laparotomy only), control (I/R only), betanin treatment (100 mg/kg of betanin administered intraperitoneally (i.p.) 60 minutes before I/R) and copper sulfate treatment group (0.1 mg/kg/day copper sulfate i.p. for 7 days before I/R). Ischemia was induced by clamping the aorta between the left renal artery and aortic bifurcation for 45 minutes. After 48-hour reperfusion, the rats were sacrificed and heart/lung tissues were harvested. Malondialdehyde (MDA), myeloperoxidase (MPO), interleukin 6 (IL-6) levels were determined. Apoptosis was determined via TUNEL assay. MDA, MPO, IL-6 levels and apoptotic cells were significantly increased in the I/R group. In both treatment groups, MDA and MPO levels were decreased. IL-6 was significantly decreased in response to betanin administration in the heart, but not in the lung; copper had no effect in either area. The numbers of apoptotic cells were significantly decreased in both treatment groups. Betanin and copper may have protective effects on I/R injury in the heart and lung in rats (Fig. 6, Ref. 39). |
| Anahtar Kelimeler |
| ischemia reperfusion injury | betanin | copper | antiinflammation | antioxidant | rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 25 |