The protective role of jervine against radiation-induced gastrointestinal toxicity2
Yazarlar (9)
Selvinaz Yakan
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Tuba Aydin
Türkiye
Canan Gulmez
Türkiye
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye
Kivilcim Eren Erdogan
Türkiye
Yusuf Kenan Daglioglu
Türkiye
Fundagul Andic
Türkiye
Onur Atakisi
Türkiye
Ahmet Cakir
Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Q1) | ||
| Dergi ISSN | 1475-6366 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Cilt / Sayı / Sayfa | 34 / 1 / 789–798 | DOI | 10.1080/14756366.2019.1586681 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1586681 | ||
| Özet |
| In this study, we investigated whether jervine (J) could prevent gastrointestinal (GI) side effects of abdominopelvic radiotherapy (RT) in Wistar-Albino female rats. Rats were divided into five groups: control (C), J only (J), J administered at 5 mg/kg/days for 7 days, RT only (RT), J before RT (J + RT), J administered for seven days before RT, J both before and after RT (J + RT + J), and J administered for 7 days before RT and after RT for 3 days. The weights of rats were measured on the 1st, 7th, and 10th days of the study. Rats were sacrificed to obtain tissues from the liver and intestine, which was followed by taking blood samples intracardially. In addition, the tissues were stained with pyruvate dehydrogenase (PDH) immunohistochemically. In our study, J supplementation markedly reduced weight loss, and histopathological, immunohistochemical, biochemical results suggest that J had a protective effect on GI toxicity following RT. |
| Anahtar Kelimeler |
| Radiotherapy | jervine | pyruvate dehydrogenase (PDH) |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 8 |