| Yazarlar |
Selvinaz Yakan
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Tuba Aydin
Türkiye |
|
Canan Gulmez
Türkiye |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye |
|
Kivilcim Eren Erdogan
Türkiye |
|
Yusuf Kenan Daglioglu
Türkiye |
|
Fundagul Andic
Türkiye |
|
Onur Atakisi
Türkiye |
|
Ahmet Cakir
Türkiye |
| Özet |
| In this study, we investigated whether jervine (J) could prevent gastrointestinal (GI) side effects of abdominopelvic radiotherapy (RT) in Wistar-Albino female rats. Rats were divided into five groups: control (C), J only (J), J administered at 5 mg/kg/days for 7 days, RT only (RT), J before RT (J + RT), J administered for seven days before RT, J both before and after RT (J + RT + J), and J administered for 7 days before RT and after RT for 3 days. The weights of rats were measured on the 1st, 7th, and 10th days of the study. Rats were sacrificed to obtain tissues from the liver and intestine, which was followed by taking blood samples intracardially. In addition, the tissues were stained with pyruvate dehydrogenase (PDH) immunohistochemically. In our study, J supplementation markedly reduced weight loss, and histopathological, immunohistochemical, biochemical results suggest that J had a protective effect on GI toxicity following RT. |
| Anahtar Kelimeler |
| Radiotherapy | jervine | pyruvate dehydrogenase (PDH) |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY |
| Dergi ISSN | 1475-6366 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2019 |
| Cilt No | 34 |
| Sayı | 1 |
| Sayfalar | 789 / 798 |
| Doi Numarası | 10.1080/14756366.2019.1586681 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1586681 |
| Atıf Sayıları | |
| WoS | 4 |
