Inhibition of Sirtuin 6 Induces Neuroblastoma Differentiation
Yazarlar (9)
Ha Yong Song
Türkiye
Erıc J Rellınger
Türkiye
Seonghoon Park
Türkiye
Prıtha Paul
Türkiye
Jıngbo Qıao
Türkiye
Athanasıos Vasılopoulos
Türkiye
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye
Davıd Gıus
Türkiye
Daı H Chung
Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ANTICANCER RESEARCH | ||
| Dergi ISSN | 0250-7005 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2018 |
| Cilt / Sayı / Sayfa | 38 / 2 / 647–654 | DOI | 10.21873/anticanres.12268 |
| Makale Linki | http://ar.iiarjournals.org/content/38/2/647.abstract | ||
| Özet |
| Sirtuins (SIRTs) play crucial roles in various signaling pathways that modulate differentiation and proliferation. We sought to elucidate the role of SIRTs in differentiation and proliferation of human neuroblastoma (NB). NB cells were treated with nicotinamide (NAM), a non-specific SIRT inhibitor, SIRT-targeted short hairpin RNAs, and retinoic acid to assess cell growth and differentiation. SIRTs are involved in proliferation and differentiation using NAM in BE(2)-C cells. Specifically, SIRT6 knockdown in BE(2)-C cells reduced cell proliferation, induced neurite extension, corresponding with induction of p21 expression and G cell-cycle arrest. These effects were rescued by forced re-overexpression of SIRT6. SIRT6 expression was reduced in differentiated human NB sections, and RA-induced differentiation in BE(2)-C cells. SIRTs have important oncogenic properties in NB beyond its established functions in aging and genome stability. SIRT6 may represent a novel target for developing future therapeutics for the treatment of aggressive NBs. |
| Anahtar Kelimeler |
| Sirtuins | SIRT6 | proliferation | differentiation | neuroblastoma |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 15 |