| Yazarlar |
Jonas J Staudacher
Türkiye |
|
Jessica Bauer
Türkiye |
|
Arundhati Jana
Türkiye |
|
Jun Tian
Türkiye |
|
Timothy Carroll
Türkiye |
|
Georgina Mancinelli
Türkiye |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye |
|
Nancy Krett
Türkiye |
|
Grace Guzman
Türkiye |
|
David Kerr
Türkiye |
|
Paul Grippo
Türkiye |
|
Barbara Jung
Türkiye |
| Özet |
| Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation. Here, we examine cross-regulation and combined functions of the two most prominent TGF-β superfamily members activin and TGF-β in advanced colorectal cancer. In two clinical cohorts we observed by immune-based assay that combined serum and tissue activin and TGF-β ligand levels predicts outcome in CRC patients and is superior to single ligand assessment. While TGF-β growth suppression is independent of activin, TGF-β treatment leads to increased activin secretion in colon cancer cells and TGF-β induced cellular migration is dependent on activin, indicating pathway cross-regulation and functional interaction in vitro. mRNA expression of activin and TGF-β pathway members were queried in silico using the TCGA data set. Coordinated ligand and receptor expression is common in solid tumors for activin and TGF-β pathway members. In conclusion, activin and TGF-β are strongly connected signaling pathways that are important in advanced CRC. Assessing activin and TGF-β signaling as a unit yields important insights applicable to future diagnostic and therapeutic interventions. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Scientific Reports |
| Dergi ISSN | 2045-2322 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2017 |
| Cilt No | 7 |
| Sayı | 1 |
| Doi Numarası | 10.1038/s41598-017-05907-8 |
| Makale Linki | http://www.nature.com/articles/s41598-017-05907-8 |
| Atıf Sayıları | |
| WoS | 50 |
