Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer
Yazarlar (12)
Jonas J Staudacher
Jessica Bauer
Arundhati Jana
Jun Tian
Timothy Carroll
Georgina Mancinelli
Prof. Dr. Özkan ÖZDEN Kafkas Üniversitesi, Türkiye
Nancy Krett
Grace Guzman
David Kerr
Paul Grippo
Barbara Jung
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | SCIENTIFIC REPORTS | ||
| Dergi ISSN | 2045-2322 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2017 |
| Cilt / Sayı / Sayfa | 7 / 1 / – | DOI | 10.1038/s41598-017-05907-8 |
| Makale Linki | http://www.nature.com/articles/s41598-017-05907-8 | ||
| Özet |
| Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation. Here, we examine cross-regulation and combined functions of the two most prominent TGF-β superfamily members activin and TGF-β in advanced colorectal cancer. In two clinical cohorts we observed by immune-based assay that combined serum and tissue activin and TGF-β ligand levels predicts outcome in CRC patients and is superior to single ligand assessment. While TGF-β growth suppression is independent of activin, TGF-β treatment leads to increased activin secretion in colon cancer cells and TGF-β induced cellular migration is dependent on activin, indicating pathway cross-regulation and functional interaction in vitro. mRNA expression of activin and TGF-β pathway members were queried in silico using the TCGA data set. Coordinated ligand and receptor expression is common in solid tumors for activin and TGF-β pathway members. In conclusion, activin and TGF-β are strongly connected signaling pathways that are important in advanced CRC. Assessing activin and TGF-β signaling as a unit yields important insights applicable to future diagnostic and therapeutic interventions. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 58 |