| Yazarlar |
Randa Tao
Türkiye |
|
Leclerc Jamie
Türkiye |
|
Kubra Yildiz
Türkiye |
|
Park Seong Hoon
Türkiye |
|
Jung Barbara
Türkiye |
|
David Gius
Türkiye |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye |
| Özet |
| The sirtuin (SIRT) gene family is reported to regulate critical intracellular processes from aging to cellular metabolismand repair. SIRT3 knockout (SIRT3 -/-) mice develop receptor positive mammary tumors starting at 13 months and SIRT3 expressionis decreased in human breast cancer samples as well as several other diseases. It is established that carcinogenesis results from theaccumulation of multiple aberrant genetic events including the activation of oncogenes and inactivation of tumor-suppressor genes.To determine the potential early genomic events that may play a role in the tumor-permissive phenotype observed in SIRT3-/- cells, wecompared gene expression profle in SIRT3-/- and wild-type (SIRT3 +/+) mouse livers. Diferences between the expression profles of genesimportant in the p53 and apoptosis pathway and signal transduction pathways, as well as genes involved with insulin and cholesterolmetabolism, were determined. Tese results demonstrate that the expression of several oncogenes including Cdkn1 , Myc , and Nos2 areincreased. In contrast, several genes shown to be downregulated in human breast cancer including Btg2, Egr-1 , Fos, Jun , Gadd4, andWnt1 had decreased expression. Te current work demonstrates that the loss of function of SIRT3 results in a cellular environmentpermissive for carcinogenesis and is characterized by altered metabolism. |
| Anahtar Kelimeler |
| SIRT3 | mitochondria | gene expression | cancer | metabolism | liver |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TURKISH JOURNAL OF BIOLOGY |
| Dergi ISSN | 1300-0152 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
| Cilt No | 39 |
| Sayı | 3 |
| Sayfalar | 380 / 387 |
| Doi Numarası | 10.3906/biy-1408-40 |
| Makale Linki | http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=biy-1408-40 |
| Atıf Sayıları | |
| TRDizin | 1 |
