Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity
Yazarlar (8)
Yueming Zhu
Türkiye
Seong-Hoon Park
Türkiye
Hyun-Seok Kim
Türkiye
Haiyan Jiang
Türkiye
Athanassios Vassilopoulos
Türkiye
Douglas R Spitz
Türkiye
David Gius
Türkiye
| Makale Türü |
Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği,
araştırma notu, bilirkişi raporu ve benzeri)
(SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not,
editöre mektup, tartışma, vaka takdimi ve özet türünden makale)
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| Dergi Adı | FREE RADICAL BIOLOGY AND MEDICINE | ||
| Dergi ISSN | 0891-5849 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2012 |
| Cilt / Sayı / Sayfa | 53 / 4 / 828–833 | DOI | 10.1016/j.freeradbiomed.2012.06.020 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0891584912003553 | ||
| Özet |
| Mitochondrial oxidative metabolism is the major site of ATP production as well as a significant source of reactive oxygen species (ROS) that can cause damage to critical biomolecules. It is well known that mitochondrial enzymes that scavenge ROS are targeted by stress responsive proteins to maintain the fidelity of mitochondrial function. Manganese superoxide dismutase (MnSOD) is a primary mitochondrial ROS scavenging enzyme, and in 1983 Irwin Fridovich proposed an elegant chemical mechanism/model whereby acetylation directs MnSOD enzymatic activity. He christened it the "electrostatic repulsion model." However, the biochemical and genetic mechanism(s) determining how acetylation directs activity and the reasons behind the evolutionarily conserved need for several layers of transcriptional and posttranslational MnSOD regulation remain unknown. In this regard, we and others have shown that MnSOD is regulated, at least in part, by the deacetylation of specific conserved lysines in a reaction catalyzed by the mitochondrial sirtuin, Sirt3. We speculate that the regulation of MnSOD activity by lysine acetylation via an electrostatic repulsion mechanism is a conserved and critical aspect of MnSOD regulation necessary to maintain mitochondrial homeostasis. |
| Anahtar Kelimeler |
| Electrostatic repulsion model | MnSOD | Sirt3 | Sirtuins | Metabolism | Mitochondria | ROS | Acetylation | Acetylome | Metabolic homeostasis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 56 |