| Yazarlar |
Yueming Zhu
Türkiye |
|
Seong-Hoon Park
Türkiye |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye |
|
Hyun-Seok Kim
Türkiye |
|
Haiyan Jiang
Türkiye |
|
Athanassios Vassilopoulos
Türkiye |
|
Douglas R Spitz
Türkiye |
|
David Gius
Türkiye |
| Özet |
| Mitochondrial oxidative metabolism is the major site of ATP production as well as a significant source of reactive oxygen species (ROS) that can cause damage to critical biomolecules. It is well known that mitochondrial enzymes that scavenge ROS are targeted by stress responsive proteins to maintain the fidelity of mitochondrial function. Manganese superoxide dismutase (MnSOD) is a primary mitochondrial ROS scavenging enzyme, and in 1983 Irwin Fridovich proposed an elegant chemical mechanism/model whereby acetylation directs MnSOD enzymatic activity. He christened it the "electrostatic repulsion model." However, the biochemical and genetic mechanism(s) determining how acetylation directs activity and the reasons behind the evolutionarily conserved need for several layers of transcriptional and posttranslational MnSOD regulation remain unknown. In this regard, we and others have shown that MnSOD is regulated, at least in part, by the deacetylation of specific conserved lysines in a reaction catalyzed by the mitochondrial sirtuin, Sirt3. We speculate that the regulation of MnSOD activity by lysine acetylation via an electrostatic repulsion mechanism is a conserved and critical aspect of MnSOD regulation necessary to maintain mitochondrial homeostasis. |
| Anahtar Kelimeler |
| Electrostatic repulsion model,MnSOD,Sirt3,Sirtuins,Metabolism,Mitochondria,ROS,Acetylation,Acetylome,Metabolic homeostasis |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | Free Radical Biology and Medicine |
| Dergi ISSN | 0891-5849 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2012 |
| Cilt No | 53 |
| Sayı | 4 |
| Sayfalar | 828 / 833 |
| Doi Numarası | 10.1016/j.freeradbiomed.2012.06.020 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0891584912003553 |
| Atıf Sayıları | |
| WoS | 51 |
