| Yazarlar |
Seong-Hoon Park
Türkiye |
Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye |
|
Haiyan Jiang
Türkiye |
|
Yong I Cha
Türkiye |
|
J Daniel Pennington
Türkiye |
|
Nukhet Aykin-Burns
Türkiye |
|
Douglas R Spitz
Türkiye |
|
David Gius
Türkiye |
| Özet |
| One fundamental observation in cancer etiology is that the rate of malignancies in any mammalian population increases exponentially as a function of age, suggesting a mechanistic link between the cellular processes governing longevity and carcinogenesis. In addition, it is well established that aberrations in mitochondrial metabolism, as measured by increased reactive oxygen species (ROS), are observed in both aging and cancer. In this regard, genes that impact upon longevity have recently been characterized in S. cerevisiae and C. elegans, and the human homologs include the Sirtuin family of protein deacetylases. Interestingly, three of the seven sirtuin proteins are localized into the mitochondria suggesting a connection between the mitochondrial sirtuins, the free radical theory of aging, and carcinogenesis. Based on these results it has been hypothesized that Sirt3 functions as a mitochondrial fidelity protein whose function governs both aging and carcinogenesis by modulating ROS metabolism. Sirt3 has also now been identified as a genomically expressed, mitochondrial localized tumor suppressor and this review will outline potential relationships between mitochondrial ROS/superoxide levels, aging, and cell phenotypes permissive for estrogen and progesterone receptor positive breast carcinogenesis. |
| Anahtar Kelimeler |
| Sirt3 | mitochondria | acetylation | acetylome | cancer | MnSOD | carcinogenesis | receptor positive breast cancer |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| Dergi ISSN | 1422-0067 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2011 |
| Cilt No | 12 |
| Sayı | 9 |
| Sayfalar | 6226 / 6239 |
| Doi Numarası | 10.3390/ijms12096226 |
| Makale Linki | http://www.mdpi.com/1422-0067/12/9/6226/ |
| Atıf Sayıları | |
| WoS | 84 |
