| Yazarlar |
Hyun-Seok Kim
Türkiye |
|
Krish Patel
Türkiye |
|
Kristi Muldoon-Jacobs
Türkiye |
|
Kheem S Bisht
Türkiye |
|
Nukhet Aykin-Burns
Türkiye |
|
J Daniel Pennington
Türkiye |
|
Der Meer Van
Türkiye |
|
Phuongmai Nguyen
Türkiye |
|
Jason Savage
Türkiye |
|
Kjerstin M Owens
Türkiye |
|
Athanassios Vassilopoulos
Türkiye |
Prof. Dr. Özkan ÖZDEN
Kafkas Üniversitesi, Türkiye |
|
Seong-Hoon Park
Türkiye |
|
Keshav K Singh
Türkiye |
|
Abdulkadir Sarki A
Türkiye |
|
Douglas R Spitz
Türkiye |
|
Chu-Xia Deng
Türkiye |
|
David Gius
Türkiye |
| Özet |
| The sirtuin gene family (SIRT) is hypothesized to regulate the aging process and play a role in cellular repair. This work demonstrates that SIRT3(-/-) mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial physiology as well as increases in stress-induced superoxide levels and genomic instability. Expression of a single oncogene (Myc or Ras) in SIRT3(-/-) MEFs results in in vitro transformation and altered intracellular metabolism. Superoxide dismutase prevents transformation by a single oncogene in SIRT3(-/-) MEFs and reverses the tumor-permissive phenotype as well as stress-induced genomic instability. In addition, SIRT3(-/-) mice develop ER/PR-positive mammary tumors. Finally, human breast and other human cancer specimens exhibit reduced SIRT3 levels. These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Cancer Cell |
| Dergi ISSN | 1535-6108 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2010 |
| Cilt No | 17 |
| Sayı | 1 |
| Sayfalar | 41 / 52 |
| Doi Numarası | 10.1016/j.ccr.2009.11.023 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1535610809004280 |
| Atıf Sayıları | |
| WoS | 640 |
