SIRT3 Is a Mitochondria Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
Yazarlar (18)
Hyun-Seok Kim
Türkiye
Krish Patel
Türkiye
Kristi Muldoon-Jacobs
Türkiye
Kheem S Bisht
Türkiye
Nukhet Aykin-Burns
Türkiye
J Daniel Pennington
Türkiye
Der Meer Van
Türkiye
Phuongmai Nguyen
Türkiye
Jason Savage
Türkiye
Kjerstin M Owens
Türkiye
Athanassios Vassilopoulos
Türkiye
Seong-Hoon Park
Türkiye
Keshav K Singh
Türkiye
Abdulkadir Sarki A
Türkiye
Douglas R Spitz
Türkiye
Chu-Xia Deng
Türkiye
David Gius
Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | CANCER CELL | ||
| Dergi ISSN | 1535-6108 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2010 |
| Cilt / Sayı / Sayfa | 17 / 1 / 41–52 | DOI | 10.1016/j.ccr.2009.11.023 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1535610809004280 | ||
| Özet |
| The sirtuin gene family (SIRT) is hypothesized to regulate the aging process and play a role in cellular repair. This work demonstrates that SIRT3(-/-) mouse embryonic fibroblasts (MEFs) exhibit abnormal mitochondrial physiology as well as increases in stress-induced superoxide levels and genomic instability. Expression of a single oncogene (Myc or Ras) in SIRT3(-/-) MEFs results in in vitro transformation and altered intracellular metabolism. Superoxide dismutase prevents transformation by a single oncogene in SIRT3(-/-) MEFs and reverses the tumor-permissive phenotype as well as stress-induced genomic instability. In addition, SIRT3(-/-) mice develop ER/PR-positive mammary tumors. Finally, human breast and other human cancer specimens exhibit reduced SIRT3 levels. These results identify SIRT3 as a genomically expressed, mitochondria-localized tumor suppressor. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 678 |