| Yazarlar |
Süleyman Sami Çakır
Türkiye |
|
Levent Özcan
Türkiye |
|
Emre Can Polat
Türkiye |
|
Hüseyin Beşiroğlu
Türkiye |
Prof. Dr. Ramazan KOCAASLAN
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Alper Ötünçtemur
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Emin Özbek
İstanbul Üniversitesi-Cerrahpaşa, Türkiye |
| Özet |
| To compare the efficacy of statins and ɑ blockers drug therapies for benign prostatic hyperplasia (BPH) in patients with metabolic syndrome (MetS). A total of three hundred patients were randomly distributed into three groups of one hundred patients each. Group 1 received only ɑ-adrenoceptor antagonist (ɑ-blocker, AB) (Tamsulosin), group 2 received only statin (atorvastatin), and group 3 received AB plus statin (Tamsulosin + Atorvastatin). The efficacy measurement was assessed by analyzing the changes from baseline in the total International Prostate Symptom Score (IPSS), disease-specific QoL question score and maximum urinary flow rate at the end of 6 months in each group and between the three groups. Pre-treatment and post-treatment value of triglycerides (TG), high-density lipoprotein (HDL), and prostate volüme (PV) were not significantly different in AB group, while TG and PV were significantly lower in patients taking statin and combined therapy. The significant decrease was demonstrated in maximum urinary flow rate () in three groups. However, the most significant decrease was observed in the combination therapy group. IPSS, postvoid residual urine volüme (PVR), and Quality of Life score (QoL) significantly changed in three groups. We recommend of the use of statins in those men with BPH accompanied by MetS in which AB is ineffective alone. |
| Anahtar Kelimeler |
| Benign prostatic hyperplasia | metabolic syndrome | ɑ | -adrenoceptor antagonist | statin |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | AGING MALE |
| Dergi ISSN | 1368-5538 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2020 |
| Cilt No | 23 |
| Sayı | 5 |
| Sayfalar | 538 / 543 |
| Doi Numarası | 10.1080/13685538.2018.1541979 |
| Makale Linki | http://dx.doi.org/10.1080/13685538.2018.1541979 |
| Atıf Sayıları | |
| WoS | 10 |
| SCOPUS | 11 |
| Google Scholar | 15 |
