| Yazarlar |
Levent Özcan
Türkiye |
|
Emre Can Polat
Türkiye |
|
Efe Önen
Türkiye |
Prof. Dr. Ramazan KOCAASLAN
Kafkas Üniversitesi, Türkiye |
|
Alper Ötunçtemur
Türkiye |
|
Mustafa Baki Çekmen
Kocaeli Üniversitesi, Türkiye |
|
Fatma Ceyla Eraldemir
Kocaeli Üniversitesi, Türkiye |
|
Emin Özbek
Türkiye |
| Özet |
| In this study, we evaluated the effect of 5 mg tadalafil once daily in men with premature ejaculation (PE). Thirty married men with lifelong PE and 30 healthy men as control group were included in this study. All the patients received 5 mg tadalafil once a day for a month. The international index of erectile function questionnaire and intravaginal ejaculatory latency times (IELTs) and PE profile were recorded before and after treatment. Plasma samples were collected before and after treatment. The mean baseline IELTs was 40.8 ± 8.1 s in the PE group and 196.5 ± 26.2 s in the control group. After treatment in the PE group, the mean IELTs values showed a statistically significant improvement from the baseline values. At the end of 4 weeks, in the PE group, the mean IELT values showed a statistically significant improvement from the baseline values. Baseline serum nitric oxide (NO) levels were 27.3 ± 1.7 in the PE group and in the 31.1 ± 1.4 healthy control groups. After treatment, NO levels were increased from baseline. We consider that 5 mg tadalafil once daily is safety and effective for the treatment of PE. |
| Anahtar Kelimeler |
| Premature ejaculation | Tadalafil | Treatment |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | UROLOGIA INTERNATIONALIS |
| Dergi ISSN | 0042-1138 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2017 |
| Cilt No | 98 |
| Sayı | 2 |
| Sayfalar | 210 / 214 |
| Doi Numarası | 10.1159/000445839 |
| Makale Linki | http://www.karger.com/?doi=10.1159/000445839 |
| Atıf Sayıları | |
| WoS | 8 |
| SCOPUS | 9 |
| Google Scholar | 18 |
