Relationship between Prostate Size and Positive Surgical Margin in the Open Radical Prostatectomy Surgery
Yazarlar (8)
Mehmet Emin Özyalvaçlı
Bolu Abant İzzet Baysal Üniversitesi, Türkiye
Bolu Abant İzzet Baysal Üniversitesi, Türkiye
Prof. Dr. Ramazan KOCAASLAN Kafkas Üniversitesi, Türkiye
Uğur Yücetaş
T.C. Sağlık Bakanlığı
T.C. Sağlık Bakanlığı
Erkan Erkan
T.C. Sağlık Bakanlığı
T.C. Sağlık Bakanlığı
Ali Feyzullah Şahin
Şifa Üniversitesi
Şifa Üniversitesi
Prof. Dr. Mustafa Kadıhasanoğlu T.C. Sağlık Bakanlığı
Prof. Dr. Yusuf Şahin T.C. Sağlık Bakanlığı
Erdinç Ünlüer
Kafkas Üniversitesi
Kafkas Üniversitesi
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Özgün Makale
(Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale)
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| Dergi Adı | Acta Medica Anatolia | ||
| Dergi ISSN | 2148-2357 | ||
| Dergi Tarandığı Indeksler | türk atıf dizini | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2016 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2016 |
| Cilt / Sayı / Sayfa | 4 / 3 / 107–111 | DOI | 10.5505/actamedica.2016.30502 |
| Makale Linki | http://www.journalagent.com/z4/download_fulltext.asp?pdir=actamedica&plng=eng&un=ACTAMED-30502 | ||
| UAK Araştırma Alanları |
Üroloji
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| Özet |
| Results: Stage T3 and PSA> 10 ng/dL were statistically significant for positive surgical margins (p= 0,002 and p< 0,001, respectively). The number of positive cores and Gleason score from these biopsies was also statistically higher in those with positive surgical margins (p= 0,002 and p< 0,001, respectively). In the multivariate logistic regression analysis, the risk for PCM was found to be 2.67 times higher in patients with PSA> 10 ng/dL (95% CI: 1.18 to 6.04; p= 0.018) and stage T3 increased the risk for PCM by 8.51 times (95% CI: 3.54 to 20.51, p=< 0.001). When we performed AUROC analysis to determine the positivity of surgical margin in terms of prostate volume, we achieved a cutoff value of 34.5 with 55% sensitivity and 71% specificity (AUC: 0.646, 95% CI: 0.555 to 0.737, p= 0.002). Again, any value above 34.5 cc was found to statistically significantly increase the risk for PCM by 2.86 times (95% CI: 1.31 to 6.28; p= 0.009).Conclusion: We found that the prostate volume had an important role in positivity of surgical margins. It is likely that addition of prostate volume as well to nomograms used before surgery may be useful in improving of risk assessment in prostate cancer. Furthermore, evaluation of the prostate volume can be used as a prognostic factor for prostate cancer. |
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BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 1 |