| Yazarlar |
Fikriye Polat
Türkiye |
|
Egemen Dere
Türkiye |
|
Eylem Gül
Türkiye |
|
İzzet Yelkuvan
Türkiye |
Prof. Dr. Öztürk ÖZDEMİR
Türkiye |
|
Günsel Bingöl
Türkiye |
| Özet |
| This study examined the effects of separate and combined applications of 3-methylcholanthrene, a polycyclic aromatic hydrocarbon and potent carcinogenic agent, and butylated hydroxytoluene, the antioxidant food additive, on the glycogen levels of liver, muscle, testis, and tumor tissues in rats. Adult male Wistar albino rats weighing 100 110 g at 8 weeks of age were used in this study. This study consisted of a control group (n = 9) and 3 different experiment groups in which rats were chronically treated with 3-methylcholanthrene (n = 9) or butylated hydroxytoluene (n = 11) or a combination of these agents (n = 14). Rats were intraperitoneally injected with a 200 mg kg −1 dose of butylated hydroxytoluene and a 40 mg kg1 dose of 3-methylcholanthrene. At the end of the 26-week experimental period, tissues of rats killed via cervical dislocation were placed in 10% trichloroacetic acid for glycogen determination. Our results showed that the administration of 3-methylcholanthrene, butylated hydroxytoluene, and 3-methylcholanthrene + butylated hydroxytoluene caused statistically significant changes in the glycogen levels of liver, muscle, and testis tissues, and glycogen was stored in tumor tissue. |
| Anahtar Kelimeler |
| rats,3-methylcholanthrene,carcinogens,glycogen,butylated hydroxyanisole,food additives,neoplasms,polycyclic hydrocarbons |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Turkish Journal of Biology |
| Dergi ISSN | 1300-0152 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2013 |
| Cilt No | 37 |
| Sayı | 1 |
| Sayfalar | 33 / 38 |
| Doi Numarası | 10.3906/biy-1010-126 |
| Makale Linki | http://dx.doi.org/10.3906/biy-1010-126 |
| Atıf Sayıları | |
| TRDizin | 1 |
