| Yazarlar |
Betul Sargın
Türkiye |
|
Ayla Akbal
Türkiye |
|
Hatice Reşorlu
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
|
Yılmaz Savaş
Sivas Cumhuriyet Üniversitesi, Türkiye |
|
Coşkun Zateri
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
|
Fatma Sılan
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
Prof. Dr. Öztürk ÖZDEMİR
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
| Özet |
| Objective. We aimed to evaluate the frequency of toll-like receptor 4 (TLR4) gene polymorphism and itsrelationship between disease activity in patients with ankylosing spondylitis (AS). Methods. Forty-one ASpatients (25 male/16 female) fullfilling the 1984 Modified New York Criteria and 41 healthy controls (25male/16 female) were included in this study. Disease activity of the AS patients was assesed by Bath AnkylosingSpondylitis Disease Activity Index (BASDAI). The TLR4 gene polymorphism of AS patients and healthycontrols were analyzed by Real-Time Polymerase Chain Reaction (PCR) System. Results. Three (7.3%) patientswith AS had TLR4 gene polymorphism compared with healthy controls (0/41; 0%). Two of these patients hadheterozygous mutation and one had homozygous mutation. Significant correlation was not found betweenTLR4 gene polymorphism and BASDAI score (p > 0.05). Conclusions. In our study, TLR4 gene polymorphismwas higher in patients with AS compared with control group. But, this polymorphism was not associated withdisease activity, erythrocyte sedimentation rate and C-reactive protein levels |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | The European Research Journal |
| Dergi ISSN | 2149-3189 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2018 |
| Cilt No | 4 |
| Sayı | 2 |
| Sayfalar | 106 / 111 |
| Doi Numarası | 10.18621/eurj.346968 |
| Makale Linki | https://dergipark.org.tr/en/pub/eurj/issue/32986/346968 |
| Atıf Sayıları |
