The frequency of toll-like receptor 4 gene polymorphism in ankylosing spondylitis and its relationship between disease activity
Yazarlar (7)
Betul Sargın
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Ayla Akbal
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Hatice Reşorlu Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Yılmaz Savaş
Sivas Cumhuriyet Üniversitesi, Türkiye
Sivas Cumhuriyet Üniversitesi, Türkiye
Coşkun Zateri Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Fatma Sılan Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Prof. Dr. Öztürk ÖZDEMİR Çanakkale Onsekiz Mart Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | The European Research Journal | ||
| Dergi ISSN | 2149-3189 | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2018 |
| Cilt / Sayı / Sayfa | 4 / 2 / 106–111 | DOI | 10.18621/eurj.346968 |
| Makale Linki | https://dergipark.org.tr/en/pub/eurj/issue/32986/346968 | ||
| Özet |
| Objective. We aimed to evaluate the frequency of toll-like receptor 4 (TLR4) gene polymorphism and itsrelationship between disease activity in patients with ankylosing spondylitis (AS). Methods. Forty-one ASpatients (25 male/16 female) fullfilling the 1984 Modified New York Criteria and 41 healthy controls (25male/16 female) were included in this study. Disease activity of the AS patients was assesed by Bath AnkylosingSpondylitis Disease Activity Index (BASDAI). The TLR4 gene polymorphism of AS patients and healthycontrols were analyzed by Real-Time Polymerase Chain Reaction (PCR) System. Results. Three (7.3%) patientswith AS had TLR4 gene polymorphism compared with healthy controls (0/41; 0%). Two of these patients hadheterozygous mutation and one had homozygous mutation. Significant correlation was not found betweenTLR4 gene polymorphism and BASDAI score (p > 0.05). Conclusions. In our study, TLR4 gene polymorphismwas higher in patients with AS compared with control group. But, this polymorphism was not associated withdisease activity, erythrocyte sedimentation rate and C-reactive protein levels |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |