| Yazarlar |
Ugur Gönlügür
Türkiye |
|
Tanseli Gönlügür
Türkiye |
Prof. Dr. Öztürk ÖZDEMİR
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
|
Fatma Sılan
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
| Özet |
| Warfarin is the most widely prescribed anticoagulant in the world. Patients who need more than 15 mg per day should be considered warfarin-resistant. Nearly 30 genes have been reported in association with warfarin pharmacogenetics but genetic polymorphisms in the genes encoding CYP2C9 and VKORC1 have been shown to act as the most important determinants of drug dosage requirements. The major enzyme responsible for the metabolism of S-warfarin, the more potent of warfarin’s two stereoisomers, is CYP2C9. Warfarin inhibits vitamin K epoxide reductase (VKOR). A 30-year-old woman was referred to our clinic for pulmonary embolism. She was treated with low molecular weight heparin. The warfarin dose was titrated up to 15 mg daily but after one week, the INR (international normalized ratio) was still subtherapeutic level at 1.8. In this paper, we discuss underlying genetic polymorphisms about warfarin resistance. |
| Anahtar Kelimeler |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | ESCI dergilerinde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | EURASIAN JOURNAL OF EMERGENCY MEDICINE |
| Dergi ISSN | 2149-6048 |
| Dergi Tarandığı Indeksler | SSCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2019 |
| Cilt No | 18 |
| Sayı | 1 |
| Sayfalar | 61 / 63 |
| Doi Numarası | 10.4274/eajem.galenos.2018.41033 |
