Macular and choroidal thickness of children with Familial Mediterranean Fever gene mutation
Yazarlar (6)
Doç. Dr. Fatih Battal Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Doç. Dr. Hakan Aylanç Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Arş. Gör. Şule Yıldırım İstinye Üniversitesi, Türkiye
Ekim Yeliz
Prof. Dr. Fatma Sılan Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Prof. Dr. Öztürk ÖZDEMİR Çanakkale Onsekiz Mart Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale)
|
||
| Dergi Adı | Family Practice and Palliative Care | ||
| Dergi ISSN | 2458-8865 | ||
| Dergi Tarandığı Indeksler | DOAJ, Index Copernicus | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2017 |
| Kabul Tarihi | 02-03-2018 | Yayınlanma Tarihi | 19-04-2018 |
| Cilt / Sayı / Sayfa | – / 0 / 23–28 | DOI | 10.22391/fppc.368676 |
| Makale Linki | http://dergipark.gov.tr/doi/10.22391/fppc.368676 | ||
| UAK Araştırma Alanları |
Tıbbi Genetik
|
||
| Özet |
| Introduction: The present study aimed to evaluate macular and choroidal thicknesses in children with MEFV gene mutations.Methods: Thirty-five children with MEFV gene mutations and 40 healthy controls were included in the study. MEFV gene profiles for the current cohort were genotyped by Pyrosequencing and direct Sanger sequencing techniques. The thicknesses of the macular and choroid of each subject’s right eye were measured using spectral-domain optic coherence tomography.Results: Mean arteriolar and venular diameters were 95.75±11.98 µm and 127.61±10.44 µm in children with the MEFV gene mutations and 110.19±11.10 µm and 138.54±10.04 µm in control group respectively. Children with the MEFV gene mutations were found to have a significantly less mean arteriolar diameter (p<0.001), mean venular diameter (p<0.001), less macular thickness (p=0.016), and less choroidal thickness (p=0.014) compared to healthy controls. Conclusion: Children with the MEFV gene mutations had narrowing of the retinal arterioles, retinal venules, and macular and choroidal thinning. Future studies should aim to investigate endothelial dysfunction in children with Familial Mediterranean Fever by non-invasive and effective methods. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |