Association Between ApoE4 Allele and Deep Venous Thrombosis: A Pilot Study
Yazarlar (7)
Prof. Dr. Nurkay Katrancıoğlu Cumhuriyet Üniversitesi, Türkiye
Şinasi Manduz
Sivas Cumhuriyet Üniversitesi, Türkiye
Sivas Cumhuriyet Üniversitesi, Türkiye
Filiz Ozen
Prof. Dr. Mehmet Birhan Yılmaz Dokuz Eylül Üniversitesi, Türkiye
Erhan Atahan
Prof. Dr. Öztürk ÖZDEMİR Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Ocal Berkan
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | ||
| Dergi ISSN | 1076-0296 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2011 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 13-10-2009 |
| Cilt / Sayı / Sayfa | 17 / 2 / 225–228 | DOI | 10.1177/1076029609348646 |
| Makale Linki | https://journals.sagepub.com/doi/10.1177/1076029609348646 | ||
| UAK Araştırma Alanları |
Tıbbi Genetik
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| Özet |
| Introduction: Deep vein thrombosis (DVT) is a multifactorial disease with genetic and acquired risk factors playing in concert in its pathogenesis. ApoE gene polymorphisms seem to have some impact among patients with cardiovascular disease; however, association between DVT and ApoE gene polymorphism has not been evaluated. Materials and Methods: We aimed to search the relative frequencies ApoE alleles among patients with DVT and healthy participants. We enrolled 59 consecutive patients with DVT and 59 age- and sex-matched healthy controls. Results: In the DVT group, E3/E4 gene polymorphism was detected in 20 patients (33.9%), in the control group E3/E4 polymorphism was detected in six patients (10.2%; P = .002). In the multivariable regression analysis, E3/E4 was independently associated with 1.31-fold increased risk of DVT (odds ratio [OR] 1.31; 95% confidence interval [CI], 1.30-10.48). Conclusion: It seems there is a relationship between ApoE3/E4 gene polymorphism and DVT in the Turkish population. However, this pilot study should be supported with large-scale studies. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |