The relationship between C reactive protein rs3091244 polymorphism and ankylosing spondylitis
Yazarlar (7)
Ayla Akbal
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Prof. Dr. Hatice Reşorlu Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Ferhat Gökmen
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Yılmaz Savaş
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Dr. Öğr. Üyesi Coşkun Zateri Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Prof. Dr. Fatma Sılan Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Prof. Dr. Öztürk ÖZDEMİR Çanakkale Onsekiz Mart Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | International Journal of Rheumatic Diseases | ||
| Dergi ISSN | 1756-1841 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2015 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 20-10-2015 |
| Cilt / Sayı / Sayfa | – / 0 / – | DOI | 10.1111/1756-185X.12619 |
| Makale Linki | http://doi.wiley.com/10.1111/1756-185X.12619 | ||
| UAK Araştırma Alanları |
Fiziksel Tıp ve Rehabilitasyon
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| Özet |
| AbstractAimsPrevious studies have shown thatC‐reactive protein(CRP) gene polymorphism can be related to inflammatory changes. The present study aimed to examine the association betweenCRPgene polymorphism and clinical and laboratory findings in ankylosing spondylitis (AS) patients.Materials and methodsA total of 80 patients, 40 withASand 40 controls, were included in the study. Diagnosis ofASwas made according to Assessment inASInternational Working Group criteria. Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index and Bath Ankylosing Spondylitis Radiology Index scores were evaluated.CRPgene C, A and T alleles were evaluated and were determined using the analysis of melting curves after real time polymerase chain reaction. The odds ratios were calculated for all alleles and haploids of theCRPgene. We investigated the relationship between theCRPpolymorphism and clinical and laboratory findings.ResultsA, C, T allele frequencies in the control group were 15%, 57.5% and 27.5%. The allele frequencies in theASgroup were 38%, 68.8% and 26.2%. While C and T allele frequencies were shown to be similar in the two groups, A allele frequency was higher in theASgroup compared to the control group. TheCCwild allele was 42.5% in the control group and 47.5% in theASgroup (P= 1.0). Odds ratios for the C allele were 1.6, for theCChaploid 1.2 and for theCThaploid 3.7. Chest expansion and finger‐to‐ground distance was better in theCRPgene polymorphism group compared to the no polymorphism group.ConclusionThe presence of theCRPgeneCCwild haploid and C allele in patients may indicate an increased risk forAS. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |