| Yazarlar |
Adnan Yalçın Demirci
Türkiye |
|
Yahya Güvenç
Marmara Üniversitesi, Türkiye |
|
Ersin Özeren
Türkiye |
|
Çetin Akyol
Türkiye |
Doç. Dr. Pınar BAYRAM
Türkiye |
|
Deniz Billur
Türkiye |
|
Sevim Aydın
Türkiye |
|
Hakan Seçkin
Türkiye |
|
Kazım Yiğitkanlı
Türkiye |
| Özet |
| Background/aim: This study investigated the effect of vascular endothelial growth factor (VEGF) inhibitor bevacuzimab (BVZ) on the rabbit basilar artery using an experimental subarachnoid hemorrhage (SAH) model. Materials and methods: Eighteen adult male New-Zealand white rabbits were randomly divided into three groups: a control group (n = 6), SAH group (n = 6), and SAH+BVZ group (n = 6). Experimental SAH was created by injecting autologous arterial blood into the cisterna magna. In the treatment group, the subjects were administered a daily dose of 10 mg/kg, intravenous BVZ for 2 days after the SAH. Basilar artery diameters were measured with magnetic resonance angiography (MRA) 72 h after the SAH in all groups. After 72 h, whole brains, including the upper cervical region, were obtained from all the animals after perfusion and fixation of the animal. The wall thickness, luminal area, and the apoptosis at the basilar arteries were evaluated in all groups. Results: BVZ significantly prevented SAH-induced vasospasm confirmed in vivo with MRA imaging with additional suppression of apoptosis on basilar artery wall. Conclusion: VEGF inhibition with BVZ has shown to have a vasospasm and apoptosis attenuating effect on basilar artery in a SAH model.Key words: Apoptosis, bevacizumab, subarachnoid hemorrhage, vasoconstriction, vascular endothelial growth factors |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TURKISH JOURNAL OF MEDICAL SCIENCES |
| Dergi ISSN | 1300-0144 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2021 |
| Cilt No | 51 |
| Sayı | 5 |
| Sayfalar | 2698 / 2704 |
| Doi Numarası | 10.3906/sag-2001-230 |
| Makale Linki | https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=1099&context=medical |
| Atıf Sayıları |
