| Yazarlar |
Dr. Öğr. Üyesi Samet KIRAT
Kafkas Üniversitesi, Türkiye |
Utku Akgör
Türkiye |
| Özet |
| OBJECTIVE: This study aims to investigate the prognostic value of the preoperative neutrophil-to-lym- phocyte ratio and platelet-to-lymphocyte ratio in patients with epithelial ovarian cancer. STUDY DESIGN: Between January 2012 and December 2018, the data and preoperative levels of neu- trophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio of 116 epithelial ovarian cancer patients were retrospectively collected. The association of these relevant markers with outcomes was analyzed. RESULTS: The difference was observed concerning optimal and suboptimal debulking in platelet-to- lymphocyte ratio ratios ( p=0.04). Lymphovascular space involvement was significantly associated with higher platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio ratios ( p<0.0001). Patients with ascites and lymph node involvement had a higher platelet-to-lymphocyte ratio ratio ( p=0.007 and p=0.004). In recurrences, higher ratios of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were observed ( p=0.03 and p=0.02). The analysis revealed that platelet-to-lymphocyte ratio and neu- trophil-to-lymphocyte ratio were not independent prognostic factors for recurrence ( p=0.783 and p=0.391). Regarding mortality, platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were not independently prognostic (p=0.621 and p=0.830). It was determined that neutrophil-to-lymphocyte ratio >2.45 (HR 0.714, CI 0.622-0.794, p<0.0001) and platelet-to-lymphocyte ratio >179.4 (HR 0.736, CI 0.646-0.814, p<0.0001) could predict the presence of recurrence with a certain sensitivity and speci- ficity, and for predicting the death, a neutrophil-to-lymphocyte ratio of >2.45 had a sensitivity of 78.26% (95% CI: 56.3 to 92.5%) and a specificity of 54.84% (95%CI: 44.2 - 65.2) ( p=0.03). CONCLUSION: The evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio is im- portant in obtaining prognostic information before surgery. However, no significant association between the neutrophil-to-lymphocyte ratio or platelet-to-lymphocyte ratio with survival was identified. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | Mebas Medikal Basin Yayin Ltd. Sti |
| Dergi ISSN | 1300-4751 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2021 |
| Doi Numarası | 10.21613/GORM.2021.1247 |
| Makale Linki | http://dx.doi.org/10.21613/gorm.2021.1247 |
| Atıf Sayıları |
