A novel therapeutics agent: antioxidant effects of hydroxylfasudil on rat kidney and liver tissues in a protamine sulphate-induced cystitis rat model preliminary results
Yazarlar (10)
Aliseydi Bozkurt Erzincan Binali Yıldırım Üniversitesi, Türkiye
Harun Budak Atatürk Üniversitesi, Türkiye
Hüseyin Serkan Erol Kastamonu Üniversitesi, Türkiye
Prof. Dr. Serpil CAN Kafkas Üniversitesi, Türkiye
Tolga Mercantepe Recep Tayyip Erdoğan Üniversitesi, Türkiye
Yiğit Akın İzmir Katip Çelebi Üniversitesi, Türkiye
İsa Özbey Atatürk Üniversitesi, Türkiye
Murat Çankaya Erzincan Binali Yıldırım Üniversitesi, Türkiye
Mesut Bünyami Halıcı Atatürk Üniversitesi, Türkiye
Taha Abdulkadir Çoban Erzincan Binali Yıldırım Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Artificial Cells, Nanomedicine, and Biotechnology | ||
| Dergi ISSN | 2169-1401 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2018 |
| Cilt / Sayı / Sayfa | 9 / 0 / 1–6 | DOI | 10.1080/21691401.2018.1449120 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1449120 | ||
| Özet |
| Cystitis is defined as an inflammation of the bladder caused by a bacterial infection, and it can be dangerous and painful when it spreads through the internal organs. In this study, antioxidant effects of hydroxylfasudil (HF) at the enzymatic and molecular level on kidney and liver tissues in cystitis rat model, which is caused by inflammation of the rat bladder with a protamine sulphate (PS), was examined. Quantitative changes of reduced glutathione (GSH) and lipid peroxidation (LPO) levels, which are a marker for oxidative stress, were determined in rat kidney and liver tissues for each groups. And then molecular and biochemical impact of HF treatment on antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT) in cystitis model were studied. The results suggest that HF could be beneficial to the renal and hepatic antioxidant system. Thus, HF might be used as a novel therapeutics agent to eliminate interstitial cystitis. |
| Anahtar Kelimeler |
| Interstitial cystitis | hydroxyfasudil | expression | enzyme activity | kidney | liver |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 7 |