| Yazarlar |
Doç. Dr. Uğur AYDIN
Türkiye |
Doç. Dr. Emin KARAKURT
Türkiye |
Prof. Dr. Serpil DAĞ
Türkiye |
Prof. Dr. Enver BEYTUT
Kafkas Üniversitesi, Türkiye |
Prof. Dr. İsa ÖZAYDIN
Türkiye |
Dr. Öğr. Üyesi Hilmi NUHOĞLU
Türkiye |
Uğur Yıldız
Türkiye |
Arş. Gör. Ayfer YILDIZ UYSAL
Türkiye |
|
Emre Kurtbaş
Türkiye |
| Özet |
| Fibropapilloma is the most common neoplasic formation associated with bovine papillomavirus type I. It occurs inside the penis of bulls and causes clinically adverse effects, such as phimosis, paraphimosis, urethral stricture, and urinary retention. This study aimed to conduct a clinical and immunohistochemical evaluation of penile tumors, which are associated with adverse outcomes with regard to breeding value and yield in bulls.A total of 40 bulls of different breeds aged between 10 months to 3 years were included in the study. Tumor tissue samples collected postoperatively were fixed in 10% buffered formaldehyde solution. The avidin–biotin–peroxidase method was used for immunohistochemical staining. Three separate areas were examined under 40X objective lens for each fibropapilloma tissue. The immunoreactivity was classified as none (-), mild (+), moderate (++), and severe (+++). Fibropapillomas ranged from 2 to 10 cm in diameter. Thirty-two papillomas were pedunculated and eight were sessile and attached to the body; 30 were solitary and 10 were multiple. There were 13 relapsed cases and 27 non-relapsed cases. Immunohistochemical examination revealed a statistically significant difference in the binary comparisons of proliferating cell nuclear antigen (PCNA) and hypoxanthine-guanine phosphoribosyltransferase (HPRT) based on positive cell scoring between the relapsed and non-relapsed cases. In conclusion, cancer markers such as PCNA and HPRT can be used to evaluate the prognosis and malignancy of penile tumors that cause significant economic losses. |
| Anahtar Kelimeler |
| Fibropapilloma,cattle,hypoxanthine-guanine phosphoribosyltransferase,proliferating cell nuclear antigen,penile tumor. |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | Journal of Advances in VetBio Science and Techniques |
| Dergi ISSN | 2548-1150 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2022 |
| Doi Numarası | 10.31797/vetbio |
| Atıf Sayıları |
