| Yazarlar (11) |
Özlem Yayar
Türkiye |
|
Barış Eser
Hitit Üniversitesi, Türkiye |
|
Mehmet Büyükbakkal
Türkiye |
|
Bülent Erdoğan
Türkiye |
|
Zafer Ercan
Türkiye |
|
Özgür Merhametsiz
Türkiye |
|
Ayhan Haspulat
Türkiye |
|
Alaattin Kali
Türkiye |
|
Tolga Yıldırım
Hacettepe Üniversitesi, Türkiye |
Prof. Dr. Başol CANBAKAN
Kafkas Üniversitesi, Türkiye |
|
Mehmet Deniz Aylı
Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
AimAtherosclerotic cardiovascular disease is one of the major causes of mortality and morbidity in peritoneal dialysis (PD) patients. S100A12 is an endogenous receptor ligand of advanced glycation end-products. It was shown to contribute to the development of atherosclerosis in animal models. The aim of this study was to evaluate the relationship between S100A12 levels and carotid atherosclerosis in PD patients.MethodsA cross-sectional study was performed in 56 PD patients and 20 control subjects. Plasma S100A12 levels were measured from all participants beside routine laboratory evaluation. All subjects underwent high-resolution B-mode ultrasonography to determine carotid intima media thickness (CIMT). S100A12 levels were compared between patient and control groups. Correlation analyses of S100A12 with other laboratory values and CIMT were also performed.ResultsPlasma S100A12 levels were higher in PD patients compared with control subjects (129.5 ± 167.2 ng/mL vs. 48.5 ± 30.3 ng/mL, respectively, p < 0.001). In the patient group, CIMT was found to be positively correlated with age (r = 0.354; p = 0.007), CRP level (r = 0.269; p = 0.045), and S100A12 (r = 0.293; p = 0.028) level while it was found to be negatively correlated with hemoglobin concentration (r = -0.264; p = 0.049). In the linear regression analysis, the model, including CRP, S100A12, age, and Hgb, was found to be significant (F: 4.177, p: 0.005). When the parameters are analyzed age and S100A12 were found to be independent determinants of CIMT (β = 0.308, p = 0.018 and β = 0.248, p = 0.049, respectively).ConclusionsThis study suggests that an elevated plasma S100A12 level was closely associated with atherosclerosis. With aging elevated plasma S100A12 may show a powerful proatherogenic potential in patients undergoing PD. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Renal Failure |
| Dergi ISSN | 0886-022X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2015 |
| Cilt No | 37 |
| Sayı | 5 |
| Sayfalar | 845 / 850 |
| Doi Numarası | 10.3109/0886022X.2015.1033633 |
| Makale Linki | http://www.tandfonline.com/doi/full/10.3109/0886022X.2015.1033633 |
| Atıf Sayıları |
