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Efficacy of Combined Plasmapheresis and IntravenousImmunoglobulin Therapy in Kidney Transplant Patients WithChronic Antibody-mediated Rejection   
Yazarlar (7)
Ebru Gök Oğuz
Türkiye
Gülay Ulusal Okyay
Türkiye
Hadim Akoğlu
Sağlık Bilimleri Üniversitesi, Türkiye
Özgür Merhametsiz
Türkiye
Tolga Yıldırım
Hacettepe Üniversitesi, Türkiye
Prof. Dr. Başol CANBAKAN Prof. Dr. Başol CANBAKAN
Kafkas Üniversitesi, Türkiye
Mehmet Deniz Aylı
Sağlık Bilimleri Üniversitesi, Türkiye
Devamını Göster
Özet

Introduction

Antibody-mediated rejections (AMRs) are critical clinical issues encountered in short- and long-term follow-up of kidney transplant patients. Whereas plasmapheresis is a mainstay treatment option in acute AMR cases, there is a paucity of data regarding its efficacy in management of chronic AMR. This report describes our experience addressing this issue.

Materials and methods

We retrospectively investigated the data of 7 kidney transplant patients diagnosed with chronic AMR who were on 5 sessions of plasmapheresis (1 to 2 volume exchanges with fresh frozen plasma) on alternate days and 200 mg/kg of intravenous immunoglobulin after each session of plasmapheresis.

Results

At 6 months after the initiation of treatment, 6 patients experienced partially improved kidney function. One patient had no response and her kidney function progressively deteriorated.

Conclusions

Our preliminary results are encouraging for the combination of plasmapheresis and intravenous immunoglobulin as an adjunctive therapy for kidney transplant patients suffering from chronic AMR.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Iranian Journal of Kidney Diseases
Dergi ISSN 1735-8582 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 05-2016
Cilt No 10
Sayı 3
Sayfalar 151 / 155
Makale Linki http://www.ijkd.org/index.php/ijkd/article/view/2413/845
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