| Yazarlar (10) |
Ebru Gök Oğuz
Türkiye |
|
Güner Karaveli Gürsoy
Türkiye |
|
Özlem Yayar
Türkiye |
|
Tolga Yıldırım
Hacettepe Üniversitesi, Türkiye |
|
Tolga Çimen
Türkiye |
|
Cengiz Bulut
Türkiye |
|
Barış Eser
Hitit Üniversitesi, Türkiye |
Prof. Dr. Başol CANBAKAN
Kafkas Üniversitesi, Türkiye |
|
Ekrem Yeter
Türkiye |
|
Mehmet Deniz Aylı
Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
IntroductionLeft ventricular hypertrophy (LVH) is one of the most common cardiac abnormalities in patients with end stage renal disease (ESRD). Hypertension, diabetes, increased body mass index, gender, age, anemia, and hyperparathyroidism have been described as risk factors for LVH in patients on dialysis. However, there may be other risk factors which have not been described yet. Recent studies show that renalase is associated with cardiovascular events. The aim of this study was to reveal the relation between renalase, LVH in patients under hemodialysis (HD) treatment.MethodsThe study included 50 HD patients and 35 healthy controls. Serum renalase levels and left ventricle mass index (LVMI) were measured in all participants and the relation between these variables was examined.FindingsLVMI was positively correlated with dialysis vintage and C-reactive protein (CRP) (r = 0.387, p = 0.005 and r = 0.597, p < 0.001, respectively) and was negatively correlated with residual diuresis and hemoglobin levels (r = -0.324, p = 0.022 and r = -0.499, p < 0.001, respectively). There was no significant association of renalase with LVMI in the HD patients (r = 0.263, p = 0.065). Serum renalase levels were significantly higher in HD patients (212 ± 127 ng/mL) compared to controls (116 ± 67 ng/mL) (p < 0.001). Renalase was positively correlated with serum creatinine and dialysis vintage (r = 0.677, p < 0.001 and r = 0.625, p < 0.001, respectively).DiscussionIn our study, LVMI was correlated with dialysis vintage, residual diuresis, CRP, and hemoglobin. LVMI tends to correlate with renalase and this correlation may be significant in studies with more patient numbers. The main parameters affecting renalase levels are dialysis vintage and serum creatinine. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Renal Failure |
| Dergi ISSN | 0886-022X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2016 |
| Cilt No | 38 |
| Sayı | 8 |
| Sayfalar | 1180 / 1186 |
| Doi Numarası | 10.1080/0886022X.2016.1208516 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1208516 |
| Atıf Sayıları |
