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Association Between Conjunctival and Corneal Calcification and Atherosclerotic Changes in the Carotid Artery in Maintenance Hemodialysis Patients   
Yazarlar (7)
Sinan Çalışkan
Türkiye
Azad Hekimoğlu
Türkiye
Osman Çelikay
Türkiye
Tolga Biçer
Türkiye
Prof. Dr. Başol CANBAKAN Prof. Dr. Başol CANBAKAN
Kafkas Üniversitesi, Türkiye
Mehmet Deniz Aylı
Sağlık Bilimleri Üniversitesi, Türkiye
Canan Gürdal
Türkiye
Devamını Göster
Özet

Purpose

We aimed to investigate the association between atherosclerotic changes in the common carotid artery (CA) and conjunctival and corneal calcification (CCC) in maintenance hemodialysis (MHD) patients.

Methods

Fifty eyes of MHD patients with the highest CCC scores were enrolled. CCCs were scored according to the method described by Tokuyama et al. The eyes with the highest CCC scores were selected for further analysis. According to their CCC scores, the patients were classified into 3 groups: mild (0-2 score), moderate (3-5), and severe (6-10 score). Atherosclerosis of the common CA was evaluated by determination of intima-media thickness (IMT), peak systolic (PSV) and end diastolic (EDV) flow velocities, pulsatility index, and resistive index values by using Doppler ultrasonography.

Results

The mean IMT of the CA was 0.61 ± 0.09 mm in the mild group, 0.82 ± 0.16 mm in the moderate group, and 1.21 ± 0.32 mm in the severe group (P < 0.001). The PSV and EDV were significantly higher in the severe group than in the mild and moderate groups (all, P < 0.001). The CCC score was positively correlated with the duration of hemodialysis, ocular surface disease index score, IMT, PSV, EDV, lymphocyte, calcium, and sedimentation rate. In multiple stepwise linear regression analysis, IMT was the best predictive factor for the CCC score (R = 0.812, β = 9.526 ± 1.05, and P < 0.001).

Conclusions

Our results suggest that chronic ocular ischemia due to atherosclerotic changes may have a role in the formation or progression of CCC in MHD patients.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Cornea
Dergi ISSN 0277-3740 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce
Basım Tarihi 01-2017
Cilt No 36
Sayı 1
Sayfalar 68 / 73
Doi Numarası 10.1097/ICO.0000000000001034
Makale Linki http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpagean=00003226-201701000-00015