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Effects of alpha lipoic acid and vitamin C supplementation on transforminggrowth factor alpha TGF and transforming growth factor beta 2 TGF 2 secretion in testicular tissue of diabetic rats   
Yazarlar
Prof. Dr. Sevda ELİŞ YILDIZ Prof. Dr. Sevda ELİŞ YILDIZ
Kafkas Üniversitesi, Türkiye
Buket Bakır
Namık Kemal Üniversitesi, Türkiye
Hamit Uslu
Kafkas Üniversitesi, Türkiye
Prof. Dr. Ebru KARADAĞ SARI Prof. Dr. Ebru KARADAĞ SARI
Kafkas Üniversitesi, Türkiye
Musa Karaman
Kafkas Üniversitesi, Türkiye
Özet
The effects of alpha lipoic acid and vitamin C supplementation on TGF α and TGF β2 secretion in the testicular tissue of streptozotocin-induced diabetic rats were examined by immunohistochemical methods. Rats were divided into 5 groups; group 1 (control), 2 (diabetic control), 3 (diabetes + alpha lipoic acid), 4 (diabetes + vitamin C), and 5 (diabetes + alpha lipoic acid + vitamin C). Hematoxylin and eosin staining was performed in order to examine testicular tissue histopathologically. The streptavidin-biotin-peroxidase complex method was used for histological examination and determination of TGF α and TGF β2 localization in the testicular tissue. Regarding fasting blood glucose levels, the lowest blood glucose level was detected in group 3. Fewer pathological histopathological findings were observed in groups treated with alpha lipoic acid, vitamin C, and alpha lipoic acid + vitamin C compared to the diabetes group. TGF α and TGF β2 secretions increased in groups 3, 4, and 5 compared to group 2. In conclusion, exogenous administration of alpha lipoic acid, vitamin C, and alpha lipoic acid + vitamin C increased TGF α and TGF β2 secretion in streptozotocin-induced diabetic rats.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES
Dergi ISSN 1300-0128
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 01-2015
Cilt No 39
Sayı 1
Sayfalar 50 / 56
Doi Numarası 10.3906/vet-1407-32
Makale Linki http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=vet-1407-32