Experimentally Induced Hyperthyroidism Disrupts Hippocampal Long Term Potentiation in Adult Rats
Yazarlar (6)
Eylem Taşkın Güven İstanbul Bilim Üniversitesi, Türkiye
Aişe Seda Artış İstanbul Medeniyet Üniversitesi, Türkiye
Dr. Öğr. Üyesi Soner BİTİKTAŞ Kafkas Üniversitesi, Türkiye
Prof. Dr. Nazan Dolu İzmir Üniversitesi, Türkiye
Prof. Dr. Narin Liman Erciyes Üniversitesi, Türkiye
Prof. Dr. Cem Süer Erciyes Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı NEUROENDOCRINOLOGY (Q2)
Dergi ISSN 0028-3835 Dergi Bilgileri (2011)
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce Basım Tarihi 01-2011
Cilt / Sayı / Sayfa 94 / 3 / 218–227 DOI 10.1159/000328513
Makale Linki http://www.karger.com/doi/10.1159/000328513
UAK Araştırma Alanları
Fizyoloji
Özet
<i>Background:</i> Manipulating thyroid hormones has been shown to influence learning and memory. Although a large body of literature is available on the effects of thyroid hormone deficiency on learning and memory functions during developmental or adult-onset hypothyroidism, electrophysiological findings are limited. This limitation is especially notable with respect to thyroxine administration in adult, normothyroid animals. <i>Methods:</i> Experiments were carried out on 12 adult male Wistar rats, each 9–10 months of age. Rats were randomly divided into hyperthyroid (0.2 mg/kg/day intraperitoneal thyroxine injection, for 21 days) and control groups (n = 6 animals in each group). Following spatial learning performance tests on hyperthyroid and control groups, rats were anesthetized with urethane and placed in a stereotaxic frame. A bipolar, tungsten electrode was used to stimulate the medial perforant path. A glass micropipette was inserted within the granule cell layer of the ipsilateral dentate gyrus to record field excitatory postsynaptic potentials (fEPSP). Following a 15-min baseline recording of fEPSPs, long-term potentiation (LTP) was induced by four sets of tetanic pulse trains. <i>Results:</i> Thyroxine-treated rats showed significantly worse performance in the spatial memory task and attenuated input-output relationships in the electrophysiological analyses. Treated rats also showed a lower efficacy of LTP induction when compared with controls. <i>Conclusion:</i> The present study provides clear in vivo evidence for the action of <i>L</i>-thyroxine in the impairment of synaptic plasticity and in inducing spatial memory task deficits in adult rats. These findings may explain the complaints of cognitive function reductions in hyperthyroid patients.
Anahtar Kelimeler
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Experimentally Induced Hyperthyroidism Disrupts Hippocampal Long Term Potentiation in Adult Rats

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