The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats
Yazarlar (6)
Doç. Dr. Mustafa MAKAV Kafkas Üniversitesi, Türkiye
Prof. Dr. Mushap KURU Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Şükran YEDİEL ARAS Kafkas Üniversitesi, Türkiye
Prof. Dr. Ebru KARADAĞ SARI Kafkas Üniversitesi, Türkiye
Menekşe Bulut Iğdır Üniversitesi, Türkiye
Dureyt Veziroğlu Iğdır Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | REPRODUCTIVE BIOMEDICINE ONLINE (Q1) | ||
| Dergi ISSN | 1472-6483 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2023 |
| Cilt / Sayı / Sayfa | 47 / 6 / 103332–0 | DOI | 10.1016/j.rbmo.2023.103332 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S1472648323004327?dgcid=coauthor | ||
| Özet |
| What is the effect of hydrogen-rich water on rats with polycystic ovary syndrome (PCOS)? Female rats were divided into four groups, each consisting of eight animals. The control group received a carboxymethyl cellulose (CMC) solution, the molecular hydrogen (H2) group was given hydrogen-rich water and a CMC solution, the PCOS group was administered letrozole dissolved in a CMC solution and the PCOS + H2 group was given hydrogen-rich water and letrozole dissolved in a CMC solution. Blood and tissue samples were then collected, and biochemical and histopathological analyses were conducted on the samples. The histopathological analysis showed a reduction in the number of cysts in the PCOS + H2 group compared with the PCOS group (P < 0.0001). Additionally, the malondialdehyde, cortisol and testosterone data revealed a significant decrease in the PCOS + H2 group compared with the PCOS group (P = 0.0458, P = 0.0003, P = 0.0041, respectively). The glutathione also showed a statistically significant increase in the PCOS + H2 group compared with the PCOS group (P = 0.0012). The study findings demonstrate that hydrogen-rich water reduces the number of cysts and oxidative damage in rats with PCOS. |
| Anahtar Kelimeler |
| polycystic ovary syndrome | malondialdehyde | glutathione | hydrogen rich water | rats |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 12 |