| Yazarlar |
Prof. Dr. Turgay DEPREM
Kafkas Üniversitesi, Türkiye |
Serap İlhan Aksu
Türkiye |
Prof. Dr. Serap KORAL TAŞÇI
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Seyit Ali BİNGÖL
Kafkas Üniversitesi, Türkiye |
|
Nurhayat Gülmez
Yakın Doğu Üniversitesi, Türkiye |
Prof. Dr. Şahin ASLAN
Kafkas Üniversitesi, Türkiye |
| Özet |
| Diabetes mellitus is a systemic disease that causes functional disorders in various organs and systems. In this study, we investigated theimmunohistochemical localization of hepatocyte growth factor (HGF) and proliferating cell nuclear antigen (PCNA) in the kidneys of streptozocin(STZ)-induced diabetic mice. Twenty-four Swiss albino mice were divided into three groups: control, sham and diabetic groups. STZ (100 mg/kg) was administered intraperitoneally (ip) for the development of diabetes. The avidin-biotin-peroxidase complex (ABC) technique was used todetermine HGF and PCNA immunoreactivity. In diabetic kidney tissue, there was hydropic degeneration and irregularities on the epithelium ofsome proximal and distal tubules. Narrowing was observed in some of the Bowman’s spaces. HGF and PCNA immunoreactivities were especiallyintense in the inner cortex and weak in the medulla. More intense HGF and PCNA immunoreactivities were found in the individual epithelialcells of the proximal and distal tubules. Immunoreactivities were stronger in the proximal tubules than in the distal tubules. In addition, HGF andPCNA immunoreactivities were strong in both interstitial regions and papillary ducts. HGF immunoreactivity was weaker in the diabetic groupcompared to the other groups. PCNA immunoreactivity generally decreased in the diabetic group but increased in the glomeruli of this group.The reason for the latter result was thought to be based on the increase of mesangial cells in the glomeruli. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Kafkas Universitesi Veteriner Fakultesi Dergisi |
| Dergi ISSN | 1300-6045 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2020 |
| Cilt No | 26 |
| Sayı | 3 |
| Sayfalar | 321 / 327 |
| Doi Numarası | 10.9775/kvfd.2019.23002 |
| Atıf Sayıları |
